Regina King
Huey Freeman / Riley Freeman (voice) (55 eps)
John Witherspoon
Robert Freeman (voice) (55 eps)
Cedric Yarbrough
Tom Dubois (voice) (55 eps)
Jill Talley
Sarah Dubois (voice) (55 eps)
Gary Anthony Williams
Uncle Ruckus (voice) (55 eps)
Gabby Soleil
Jazmine Dubois (voice) (55 eps)
Ed Asner
Ed Wuncler (voice) (3 eps)
Grey DeLisle
Kim Kardashian (voice) (3 eps)
Barry Sobel
Chico / Pat O'Brien (voice) (2 eps)
Jenifer Lewis
Geraldine (voice) (2 eps)
Michael B. Jordan
Pretty Boy Flizzy (voice) (1 eps)
Tiffany Thomas
Cristal (voice) (1 eps)
Dante Basco
Jigme (voice) (1 eps)
Gina Torres
Ebony Brown (1 eps)
Dennis Haysbert
Sturdy Harris (voice) (1 eps)
Candi Milo
Janet (voice) (1 eps)