Mike Judge
Hank Hill / Boomhauer (voice) (22 eps)
Kathy Najimy
Peggy Hill (voice) (22 eps)
Pamela Adlon
Bobby Hill (voice) (22 eps)
Johnny Hardwick
Dale Gribble (voice) (22 eps)
Stephen Root
Bill Dauterive (voice) (22 eps)
David Herman
Deprogrammer (voice) (12 eps)
Phil LaMarr
Earl / Bennett (voice) (3 eps)
Jonathan Joss
John Redcorn (voice) (3 eps)
Dennis Burkley
Principal Moss (voice) (3 eps)
James Sie
(voice) (2 eps)
Tara Strong
Jane #1 (voice) (2 eps)
Amy Hill
Michiko (voice) (2 eps)
Keone Young
(voice) (2 eps)
Annie O'Donnell
(voice) (2 eps)
David Carradine
Junichiro (voice) (2 eps)
Seiko Matsuda
Reporter (voice) (2 eps)
Carlos Alazraqui
Mexican Police Officer / Mr. Ortiz (voice) (1 eps)
Eliza Schneider
Charisse (voice) (1 eps)
Caitlyn Jenner
(voice) (1 eps)
Alan Rickman
King Philip (voice) (1 eps)
Jack Carter
Irwin Linker (voice) (1 eps)
Cynthia Stevenson
Sister Mary Catherine / Claire (voice) (1 eps)
Anna Faris
Lisa (voice) (1 eps)
Gary Busey
Mad Dog (voice) (1 eps)
Lupe Ontiveros
Anne (voice) (1 eps)
Ed Asner
Stinky (voice) (1 eps)
Megan Mullally
Teresa (voice) (1 eps)
Yakov Smirnoff
Yakov Smirnoff (voice) (1 eps)
Madeline Zima
Susan Clemmons (voice) (1 eps)
Vince Gill
Boomhauer's Singing Voice (voice) (1 eps)
Kathryn Harrold
Mother Superior / Mrs. Bonter (voice) (1 eps)
Jeff Goldblum
Dr. Vayzosa (voice) (1 eps)
Laura Linney
Marlene (voice) (1 eps)
Castulo Guerra
(voice) (1 eps)
Marisabel García
Lupe (voice) (1 eps)
Marcelo Tubert
(voice) (1 eps)
Kathy Bates
Patrol Officer Jane Cooper (voice) (1 eps)
Fred Willard
Chairman / Geiger (voice) (1 eps)
Andy Siegel
Oxcart-Driving Minstrel (voice) (1 eps)
Laura Dern
Serving Wench (voice) (1 eps)
Charlie Daniels
Charlie Daniels (voice) (1 eps)
Patricia Place
Betty (voice) (1 eps)
John C. McGinley
One-Armed Ronnie / Ranger (voice) (1 eps)
Dave Allen
Jesse (voice) (1 eps)
Peter Kwong
Mr. Ho (voice) (1 eps)
Denice Kumagai
(voice) (uncredited) (1 eps)
Stephanie Fybel
Jane #2 (voice) (1 eps)
Alie Ward
Becky (voice) (uncredited) (1 eps)