Megan Fox
April O'Neil
Will Arnett
Vern Fenwick
William Fichtner
Eric Sacks
Alan Ritchson
Raphael
Noel Fisher
Michelangelo
Pete Ploszek
Leonardo
Johnny Knoxville
Leonardo (voice)
Jeremy Howard
Donatello
Danny Woodburn
Splinter
Tony Shalhoub
Splinter (voice)
Tohoru Masamune
Shredder
Whoopi Goldberg
Bernadette Thompson
Minae Noji
Karai
Abby Elliott
Taylor
Madison Mason
Councilman
Taran Killam
McNaughton
K. Todd Freeman
Dr. Baxter Stockman
Paul Fitzgerald
Dr. O'Neil
Malina Weissman
Young April O'Neil
Venida Evans
Subway Hostage
Mikal Vega
Sacks Bodyguard
Harley Pasternak
Harley Pasternak
Braeson Herold
Reporter
Chris Wylde
Reporter
Chance Kelly
Mr. Rivetti
Rick Chambers
News Anchor
Leyna Nguyen
News Anchor
Derek Mears
Dojo Ninja