Robert Downey Jr.
Peter Highman
Zach Galifianakis
Ethan Tremblay
Michelle Monaghan
Sarah Highman
Jamie Foxx
Darryl
Juliette Lewis
Heidi
Danny McBride
Lonnie
RZA
Airport Screener
Matt Walsh
TSA Agent
Brody Stevens
Limo Driver
Jakob Ulrich
Patrick
Naiia Ulrich
Alex
Todd Phillips
Barry
Bobby Tisdale
Carl
Sharon Conley
Airport X-Ray
Nathalie Fay
Flight Attendant
Emily Wagner
Flight Attendant
Steven M. Gagnon
Air Marshall
Paul Renteria
Border Guard
Marco RodrÃguez
Federali Agent
Mimi Kennedy
Sarah's Mom
Tymberlee Hill
New Mother
Keegan-Michael Key
New Father
Aaron Lustig
Dr. Greene
Charlie Sheen
Charlie Harper
Jon Cryer
Alan Harper
Haji Abdullah
Airport Passenger (uncredited)
Jeremy Ambler
TSA Agent (uncredited)
Madeline Brumby
Airport Pedestrian (uncredited)
Joseph Harold
Private Johnson (uncredited)
Sarah Reagin
Airport Security Agent (uncredited)