Denzel Washington
Dr. Jerome Davenport
Derek Luke
Antwone Fisher
Malcolm David Kelley
Antwone Fisher Age 7
Joy Bryant
Cheryl Smolley
Salli Richardson-Whitfield
Berta Davenport
Leonard Earl Howze
Pork Chop
Kevin Connolly
Slim
Viola Davis
Eva May
Yolonda Ross
Nadine
Gary A. Jones
Relative (uncredited)
Cory Hodges
Antwone Fisher Age 14
James Brolin
The Captain
Charles Robinson
Howard
Earl Billings
Uncle James
Vernee Watson-Johnson
Aunt Annette
De'Angelo Wilson
Jesse
Stephen Snedden
Berkley
Novella Nelson
Mrs. Tate
Rainoldo Gooding
Grayson
Kente Scott
Kansas City
Kim Johnson
Disc Jockey
Sung Kang
Receptionist