Eric McCormack
Will Truman (24 eps)
Debra Messing
Grace Adler (24 eps)
Sean Hayes
Jack McFarland (24 eps)
Megan Mullally
Karen Walker (24 eps)
Harry Connick Jr.
Leo Markus (6 eps)
Dave Foley
Stuart Lamarack (5 eps)
John Cleese
Lyle Finster (uncredited) (4 eps)
Blythe Danner
Marilyn Truman (4 eps)
Minnie Driver
Lorraine Finster (3 eps)
Bobby Cannavale
Vince D'Angelo (3 eps)
Leslie Jordan
Beverley Leslie (3 eps)
Tim Curry
Marion Finster (2 eps)
Laura Kightlinger
Nurse Sheila (2 eps)
Eileen Brennan
Zandra (2 eps)
Jennifer Lopez
Jennifer Lopez (2 eps)
Mira Sorvino
Diane (1 eps)
James Earl Jones
Self (1 eps)
Dylan McDermott
Tom (1 eps)
Stephanie Faracy
Eva (1 eps)
Bebe Neuwirth
Bebe Neuwirth (1 eps)
Candice Bergen
Candice Bergen (1 eps)
Lela Lee
Ping (1 eps)
Chris Penn
Rudy (1 eps)
Geena Davis
Janet Adler (1 eps)
John Edward
Self (1 eps)
Stacy Galina
Debbie (1 eps)
Clifford David
Hotel Manager (1 eps)
Tim Bagley
Larry (1 eps)
Lea DeLaria
Nurse Carver (1 eps)
Tom Everett Scott
Alex (1 eps)
Barry Manilow
Self (1 eps)
Chloë Sevigny
Monet (1 eps)
Kathryn Joosten
Felicia (1 eps)
Amy Farrington
Phyllis (1 eps)
Michael Angarano
Elliot (1 eps)
Fiona Hale
Ruth (1 eps)
Lesley Ann Warren
Tina (1 eps)
Sharon Osbourne
Nonny (1 eps)
Emily Rutherfurd
Joanne (1 eps)
Kali Rocha
Stephanie (1 eps)
Kenneth Tigar
John (1 eps)
Tracey Ullman
Ann (1 eps)
Edie Falco
Deirdre (1 eps)
Sara Gilbert
Cheryl (1 eps)
Sara Paxton
Melanie (1 eps)
Suzanne Pleshette
Lois Whitley (1 eps)
Debbie Reynolds
Bobbi Adler (1 eps)
Jerry Levine
Joe (1 eps)
Peggy Lane
Woman in Sub Shop (1 eps)
Nathan Anderson
Andrew (1 eps)
Susan Leslie
Carol / Woman (1 eps)
Michael Medico
Josh (1 eps)
Jon Fleming
Russell (1 eps)
Gordon Davidson
Self (1 eps)
Alex Boling
Judge (1 eps)
Bruce Dworkin
Guy (1 eps)
Mark Cirillo
Contestant (1 eps)
Christopher Gehrman
EMT Worker (1 eps)
Gerald Downey
Clark (1 eps)
Carla Renata
Receptionist (1 eps)
Kevin Sateri
Derek (1 eps)
Dion Basco
Arpie (1 eps)
Karen Bankhead
Burnadean (1 eps)
Oliver Muirhead
Maitre D' (1 eps)
Victoria Hoffman
Waitress (1 eps)
Kelli Kirkland
Mona (1 eps)
Tim Lucason
Bartender (1 eps)
Jaimarie Bjorge
Singing Waitress (uncredited) (1 eps)
Jackie Geary
Cashier (1 eps)
Gary Riotto
Waiter (1 eps)
Adrian Mojica
Security Guard (1 eps)
Matt Champagne
Don (1 eps)
Ralph Litt
Judge Holcomb (1 eps)
Donna Ponterotto
Woman (1 eps)
Adrienne Alitowski
Woman (1 eps)
Amy Crofoot
Female Student (1 eps)
Tara O'Connor
Photographer (1 eps)
Mark Juliano
Mark Juliano (1 eps)
Jack Black
Dr. Isaac Hershberg (1 eps)
Don Perry
Bertram (1 eps)