Cliff Curtis
Reuben 'Rabbit' Palchuck (18 eps)
Derek Luke
Cameron Boone (18 eps)
Anastasia Griffith
Nancy Carnahan (18 eps)
Aimee Garcia
Nancy Carnahan (18 eps)
Kevin Rankin
EMT Tyler Briggs (18 eps)
Taylor Kinney
EMT Tyler Briggs (18 eps)
Carl Marino
Karl Sly (18 eps)
Jamey Sheridan
Dr. Joe Saviano (18 eps)
Alisha Beckum
Valencia (18 eps)
Christopher Greene
Dr. Ludden (18 eps)
Adrian Bustamante
EMT - Paramedic - Brandon Trimmer (18 eps)
Cynthia Lea Clark
Nurse Slaughter (18 eps)
Deanna Marks
Nurse Weisman (18 eps)
Jaclyn Winters
Nurse (18 eps)
James D. Weston II
Police Officer (18 eps)
Jeffrey T. Ferguson
EMT - Precision Driver (18 eps)
Karl Antony
ER Nurse (18 eps)
Steve Wharton
EMT (18 eps)
Steven Anthony Jones
Captain Basra (18 eps)
Rosalind Chao
Therapist (2 eps)
Joseph Salazar
Darrel (1 eps)
Mickey River
Todd (1 eps)