Chad L. Coleman
Dennis "Cutty" Wise (18 eps)
Glynn Turman
Clarence Royce (14 eps)
Dominic West
Jimmy McNulty (13 eps)
Lance Reddick
Cedric Daniels (13 eps)
Sonja Sohn
Kima Greggs (13 eps)
Wendell Pierce
Bunk Moreland (13 eps)
Michael Kenneth Williams
Omar Little (13 eps)
Deirdre Lovejoy
Rhonda Pearlman (13 eps)
Clarke Peters
Lester Freamon (13 eps)
J.D. Williams
Bodie Broadus (13 eps)
Jamie Hector
Marlo Stanfield (13 eps)
Andre Royo
Bubbles (13 eps)
Frankie Faison
Ervin Burrell (13 eps)
Aidan Gillen
Tommy Carcetti (13 eps)
John Doman
William Rawls (13 eps)
Seth Gilliam
Ellis Carver (13 eps)
Domenick Lombardozzi
Herc (13 eps)
Corey Parker Robinson
Leander Sydnor (13 eps)
Reg E. Cathey
Norman Wilson (13 eps)
Jim True-Frost
Roland Pryzbylewski (13 eps)
Robert Wisdom
Howard "Bunny" Colvin (13 eps)
Maestro Harrell
Randy Wagstaff (12 eps)
Gbenga Akinnagbe
Chris Partlow (uncredited) (11 eps)
Delaney Williams
Sgt. Jay Landsman (9 eps)
Rick Otto
Off. Kenneth Dozerman (7 eps)
Ramón Rodríguez
Renaldo (7 eps)
Felicia Pearson
Felicia 'Snoop' Pearson (6 eps)
Isiah Whitlock Jr.
State Sen. R. Clayton 'Clay' Davis (6 eps)
Boris McGiver
Lt. Charles Marimow (6 eps)
Brandy Burre
Theresa D'Agostino (5 eps)
Marlyne Barrett
Council President Nerese Campbell (5 eps)
Method Man
Melvin 'Cheese' Wagstaff (3 eps)
Benjamin Busch
Off. Anthony Colicchio (3 eps)
Amy Ryan
Off. Beatrice 'Beadie' Russell (3 eps)
Daniel Lee Robertson III
Shaun Williams (2 eps)
James Lewis
Marvin (uncredited) (2 eps)
Michael Kostroff
Maurice 'Maury' Levy (1 eps)
Callie Thorne
Elena McNulty (1 eps)
Sam Coppola
Former Mayor 'Young Tony' (1 eps)
Brandon Fobbs
Fruit (1 eps)
Melanie Nicholls-King
Cheryl (1 eps)
Mike D. Anderson
Ghost (uncredited) (1 eps)
Michael Hyatt
Brianna Barksdale (1 eps)
Taylor King
Zenobia Dawson (1 eps)
Susan Rome
Asst. State's Atty. Ilene Nathan (1 eps)