Dominic West
Jimmy McNulty (12 eps)
Lance Reddick
Cedric Daniels (12 eps)
Sonja Sohn
Kima Greggs (12 eps)
Wood Harris
Avon Barksdale (12 eps)
Wendell Pierce
Bunk Moreland (12 eps)
Michael Kenneth Williams
Omar Little (12 eps)
Idris Elba
Stringer Bell (12 eps)
Deirdre Lovejoy
Rhonda Pearlman (12 eps)
Clarke Peters
Lester Freamon (12 eps)
J.D. Williams
Bodie Broadus (12 eps)
Andre Royo
Bubbles (12 eps)
Frankie Faison
Ervin Burrell (12 eps)
Aidan Gillen
Tommy Carcetti (12 eps)
John Doman
William Rawls (12 eps)
Seth Gilliam
Ellis Carver (12 eps)
Domenick Lombardozzi
Herc (12 eps)
Corey Parker Robinson
Leander Sydnor (12 eps)
Jim True-Frost
Roland Pryzbylewski (12 eps)
Robert Wisdom
Howard "Bunny" Colvin (12 eps)
Benjamin Busch
Off. Anthony Colicchio (8 eps)
Ernest Waddell
Dante (7 eps)
Brandy Burre
Theresa D'Agostino (7 eps)
Gbenga Akinnagbe
Chris Partlow (uncredited) (6 eps)
Leo Fitzpatrick
Johnny Weeks (6 eps)
Chad L. Coleman
Dennis 'Cutty' Wise (6 eps)
Michael Kostroff
Maurice 'Maury' Levy (5 eps)
Isiah Whitlock Jr.
State Sen. R. Clayton 'Clay' Davis (5 eps)
Michael Hyatt
Brianna Barksdale (5 eps)
Jay Landsman
Lt. Dennis Mello (5 eps)
Anwan Glover
Slim Charles (5 eps)
Felicia Pearson
Felicia 'Snoop' Pearson (4 eps)
Brandon Fobbs
Fruit (4 eps)
Delaney Williams
Sgt. Jay Landsman (3 eps)
Callie Thorne
Elena McNulty (3 eps)
Al Brown
Maj. Stanislaus Valchek (3 eps)
Tray Chaney
Malik 'Poot' Carr (3 eps)
Glynn Turman
Mayor Clarence V. Royce (3 eps)
Richard DeAngelis
Col. Raymond Foerster (3 eps)
Method Man
Melvin 'Cheese' Wagstaff (2 eps)
Rick Otto
Off. Kenneth Dozerman (2 eps)
Clarence Clemons
Roman (2 eps)
Melanie Nicholls-King
Cheryl (2 eps)
Robert Neal Marshall
Comstat Police Major (uncredited) (2 eps)
Mike D. Anderson
Ghost (uncredited) (2 eps)
Maria Broom
Marla Daniels (2 eps)
Robert F. Chew
Joseph 'Proposition Joe' Stewart (2 eps)
Joilet Harris
Off. Caroline Massey (2 eps)
Edwina Findley
Tosha Mitchell (2 eps)
Robert X. Golphin
Crackhead (uncredited) (1 eps)
Lizz Robbins
Pretty Lesbian (uncredited) (1 eps)
Keith Johnson
Desk Sergeant (uncredited) (1 eps)
Amy Ryan
Off. Beatrice 'Beadie' Russell (1 eps)
Ken Arnold
Car Theft Reporting Lt. (uncredited) (1 eps)
James Lewis
Marvin (uncredited) (1 eps)
Hassan Johnson
Roland 'Wee-Bey' Brice (1 eps)
Erik Dellums
Dr. Randall Frazier (1 eps)
Tony D. Head
Maj. Bobby Reed (1 eps)