Dominic West
Jimmy McNulty (12 eps)
Lance Reddick
Cedric Daniels (12 eps)
Sonja Sohn
Kima Greggs (12 eps)
Wood Harris
Avon Barksdale (12 eps)
Wendell Pierce
Bunk Moreland (12 eps)
Idris Elba
Stringer Bell (12 eps)
Deirdre Lovejoy
Rhonda Pearlman (12 eps)
Clarke Peters
Lester Freamon (12 eps)
Andre Royo
Bubbles (12 eps)
Frankie Faison
Ervin Burrell (12 eps)
John Doman
William Rawls (12 eps)
Lawrence Gilliard Jr.
D'Angelo Barksdale (12 eps)
Paul Ben-Victor
Spiros "Vondas" Vondopoulos (12 eps)
Amy Ryan
Beatrice "Beadie" Russell (12 eps)
Chris Bauer
Frank Sobotka (12 eps)
Pablo Schreiber
Nick Sobotka (12 eps)
James Ransone
Chester 'Ziggy' Sobotka (12 eps)
Charley Scalies
Thomas 'Horseface' Pakusa (11 eps)
Chris Ashworth
Sergei 'Serge' Malatov (10 eps)
Jim True-Frost
Det. Roland 'Prez' Pryzbylewski (10 eps)
Domenick Lombardozzi
Detective Thomas 'Herc' Hauk (10 eps)
Delaney Williams
Sgt. Jay Landsman (9 eps)
Al Brown
Maj. Stanislaus Valchek (9 eps)
Luray Cooper
Nathaniel 'Nat' Coxson (9 eps)
Seth Gilliam
Sergeant Ellis Carver (9 eps)
Bill Raymond
The Greek (8 eps)
Melanie Nicholls-King
Cheryl (6 eps)
Kristin Proctor
Aimee (6 eps)
J.D. Williams
Preston 'Bodie' Broadus (6 eps)
Callie Thorne
Elena McNulty (5 eps)
Lev Gorn
Eton Ben-Eleazer (5 eps)
Robert F. Chew
Joseph 'Proposition Joe' Stewart (5 eps)
Teddy Cañez
George 'Double G' Glekas (5 eps)
Lance Irwin
Maui (5 eps)
Michael Hyatt
Brianna Barksdale (4 eps)
Doug Olear
FBI Spec. Agent Terrance 'Fitz' Fitzhugh (4 eps)
Tray Chaney
Malik 'Poot' Carr (4 eps)
Robert Hogan
Louis Sobotka (4 eps)
Michael Potts
Brother Mouzone (4 eps)
Maria Broom
Marla Daniels (3 eps)
S. Robert Morgan
Butchie (3 eps)
Tom Mardirosian
Agent Kristos Koutris (3 eps)
Michael Kostroff
Maurice 'Maury' Levy (2 eps)
Method Man
Melvin 'Cheese' Wagstaff (2 eps)
Isiah Whitlock Jr.
State Sen. R. Clayton 'Clay' Davis (2 eps)
Leo Fitzpatrick
Johnny Weeks (2 eps)
Kevin Murray
Special Agent Kleary (2 eps)
Hassan Johnson
Roland 'Wee-Bey' Brice (2 eps)
Erik Dellums
Dr. Randall Frazier (2 eps)
Elisabeth Noone
Joan Sobotka (2 eps)
Susan Rome
Asst. State's Atty. Ilene Nathan (2 eps)
Keith Flippen
Bruce DiBiago (2 eps)
Jeffrey Pratt Gordon
John 'Johnny Fifty' Spamanto (2 eps)
Merritt Wever
Prissy (1 eps)
Robert Wisdom
Major Howard 'Bunny' Colvin (1 eps)
Ernest Waddell
Dante (1 eps)
Wes Johnson
Security Supervisor (uncredited) (1 eps)
Fredro Starr
Marquis 'Bird' Hilton (1 eps)
Robert F. Colesberry
Det. Ray Cole (uncredited) (1 eps)
Wendy Grantham
Shardene Innes (1 eps)
Antonio D. Charity
CO Dwight Tilghman (1 eps)
Brook Yeaton
Michael 'White Mike' McArdle (1 eps)
Michael Salconi
Officer Michael 'Sanny' Santangelo (1 eps)
Gordana Rashovich
Ilona Petrovich (1 eps)