Kath Soucie
Tuffy (voice) (325 eps)
Rick Zieff
Spike (voice) (325 eps)
Grey DeLisle
Ginger (voice) (325 eps)
Joey D'Auria
Butch / Droopy (voice) (325 eps)
Gary Cole
Narrator (voice) (325 eps)
Sam Kwasman
Little Quacker (voice) (325 eps)
Stephen Stanton
Rick (voice) (273 eps)
Rachael MacFarlane
Hildie (voice) (130 eps)
Cree Summer
Beatie (voice) (130 eps)
Rene Mujica
Newt (voice) (130 eps)
Jason Alexander
Rick (voice) (52 eps)
Simon Helberg
Napoleon (voice) (52 eps)
Tom Kenny
Dr. Bigby / Hamster (voice) (52 eps)
Chris Parnell
Narrator (voice) (1 eps)
Phil Lollar
Ronnie / Monkey (voice) (1 eps)