Dan Castellaneta
Homer Simpson / Abe Simpson / Barney Gumble / Krusty (voice) (22 eps)
Julie Kavner
Marge Simpson / Patty Bouvier / Selma Bouvier (voice) (22 eps)
Nancy Cartwright
Bart Simpson / Nelson Muntz / Ralph Wiggum (voice) (22 eps)
Yeardley Smith
Lisa Simpson (voice) (22 eps)
Hank Azaria
Moe Szyslak / Chief Wiggum / Apu / Comic Book Guy / Carl (voice) (22 eps)
Harry Shearer
Ned Flanders / Mr. Burns / Smithers / Skinner / Lenny (voice) (22 eps)
Joe Mantegna
Fat Tony (voice) (4 eps)
Maggie Roswell
Luann Van Houten (voice) (3 eps)
Pete Holmes
Bode Wright (voice) (2 eps)
Jane Goodall
Jane Goodall (voice) (1 eps)
Asia Kate Dillon
Paula (voice) (1 eps)
Fortune Feimster
Evelyn (voice) (1 eps)
Charlie Brooker
Social media rating app (voice) (1 eps)
Scott Bakula
Scott Bakula (voice) (1 eps)
Jon Lovitz
Artie Ziff / Llewellyn Sinclair / other minor characters. (1 eps)
Kevin Feige
Chinnos (voice) (1 eps)
Billy Porter
Desmond (voice) (1 eps)
Chelsea Peretti
Lauren (voice) (1 eps)
Kevin Smith
Kevin Smith (voice) (1 eps)
Cate Blanchett
Elaine Wolff (voice) (1 eps)
John Legend
John Legend (voice) (1 eps)
Chrissy Teigen
Chrissy Teigen (voice) (1 eps)
Zach Woods
Zane Furlong (voice) (1 eps)
Beanie Feldstein
Support Group Therapist (voice) (1 eps)
Ed Jones
Ed Jones (voice) (1 eps)
Jim Parsons
Jim Parsons (voice) (1 eps)
Michael York
Clayton (voice) (1 eps)
Natasha Lyonne
Sophie (voice) (1 eps)
Lili Reinhart
Bella-Ella (voice) (1 eps)
Joey King
Addy (voice) (1 eps)
Madelaine Petsch
Sloan (voice) (1 eps)
Lilly Singh
Kensey (voice) (1 eps)
Camila Mendes
Tessa Rose (voice) (1 eps)
Werner Herzog
Dr. Lund (voice) (1 eps)
Drew Pinsky
Dr. Drew Pinsky (voice) (1 eps)
Dana Gould
Dana Gould (voice) (1 eps)
Tal Fishman
Reaction Guy (voice) (1 eps)
Bob Odenkirk
Mob lawyer (voice) (1 eps)
Taran Killam
Glen Tangier (voice) (1 eps)
Jason Momoa
Jason Momoa (voice) (1 eps)
Anthony Russo
Movie executive 2 (voice) (1 eps)
Steve Ballmer
Steve Ballmer (voice) (1 eps)
Kelsey Grammer
Sideshow Bob (voice) (1 eps)
Joe Russo
Movie executive 1 (voice) (1 eps)
Cobie Smulders
Hydrangea (voice) (1 eps)
Marcia Wallace
Edna Krabappel (voice) (1 eps)
Glenn Close
Mona Simpson (voice) (1 eps)
John Mulaney
Warburton Parker (voice) (1 eps)
Michael Rapaport
Mike Wegman (voice) (1 eps)
Rivers Cuomo
Rivers Cuomo (voice) (1 eps)