Dan Castellaneta
Homer Simpson / Abe Simpson / Barney Gumble / Krusty (voice) (22 eps)
Julie Kavner
Marge Simpson / Patty Bouvier / Selma Bouvier (voice) (22 eps)
Nancy Cartwright
Bart Simpson / Nelson Muntz / Ralph Wiggum (voice) (22 eps)
Yeardley Smith
Lisa Simpson (voice) (22 eps)
Hank Azaria
Moe Szyslak / Chief Wiggum / Apu / Comic Book Guy / Carl (voice) (22 eps)
Harry Shearer
Ned Flanders / Mr. Burns / Smithers / Skinner / Lenny (voice) (22 eps)
Tress MacNeille
Ms. Dare / Gwen / Homer's Cousin's Wife (voice) (18 eps)
Marcia Wallace
Edna Krabappel (voice) (7 eps)
Charles Napier
Warden (voice) (2 eps)
William Daniels
KITT (voice) (1 eps)
Nichelle Nichols
Nichelle Nichols (voice) (1 eps)
Isabel Sanford
Isabel Sanford (voice) (1 eps)
Jerry Lewis
Professor John Frink, Sr. (voice) (1 eps)
Matt Groening
Matt Groening (voice) (1 eps)
Simon Cowell
Simon Cowell (voice) (1 eps)
Jane Kaczmarek
Constance Harm (voice) (1 eps)
Dick Tufeld
Robot B-9 (voice) (1 eps)
Nick Bakay
Salem Saberhagen (voice) (1 eps)
Jon Lovitz
Artie Ziff / Llewellyn Sinclair / other minor characters. (1 eps)
Sarah Michelle Gellar
Gina Vendetti (voice) (1 eps)
Jackie Mason
Hyman Krustofsky (voice) (1 eps)
Glenn Close
Mona Simpson (voice) (1 eps)