Samantha Morton
Catherine de' Medici (8 eps)
Liv Hill
Catherine de' Medici (8 eps)
Amrita Acharia
Aabis (8 eps)
Barry Atsma
Anne de Montmorency (8 eps)
Enzo Cilenti
Cosimo Ruggeri (8 eps)
Sennia Nanua
Rahima (8 eps)
Kiruna Stamell
Mathilde (8 eps)
Nicholas Burns
Antoine de Bourbon (8 eps)
Beth Goddard
Antoinette de Bourbon (8 eps)
Raza Jaffrey
Francis de Guise (8 eps)
Danny Kirrane
Louis de Bourbon (8 eps)
Ray Panthaki
Charles de Lorraine (8 eps)
Ludivine Sagnier
Diane de Poitiers (4 eps)
Paul Chahidi
Charles de Bourbon (1 eps)
Navid Negahban
Claude de Lorraine (1 eps)
Alex Heath
Henry II of France (1 eps)
Ruby Bentall
Angelica (1 eps)
Louis Landau
Francis III of Brittany (1 eps)
Naomi Battrick
Anne de Pisseleu d'Heilly (1 eps)
Colm Meaney
Francis I of France (1 eps)
Charles Dance
Clement VII (1 eps)
Adam Garcia
Sebastiano de Montecuccoli (1 eps)
Rebecca Gethings
Eleanor of Austria (1 eps)
Memet Ali Alabora
Suleiman I of Turkey (1 eps)
Gemma Dobson
Nathalie (1 eps)
Anna Cottis
Cook (1 eps)
Delcho Koprivshki
Lorenzo de' Medici (1 eps)
Pierre Cevaer
Footman (1 eps)
Loïc Azorin
Footman (1 eps)
David Pearse
Cardinal (1 eps)
Raphael Roger Levy
Leader of Soldiers (1 eps)
Lucy Edkins
Mother Superior (1 eps)
Antonin Totot
Catherine's Guard (1 eps)
Nicolas Buchoux
Doctor (Pope) (1 eps)
Carlotta Moraru
Prostitute (1 eps)
Barbara Laurent
Prostitute (1 eps)
Simon Parmentier
Antoine de Bourbon (1 eps)
Nathan Parent
Louis de Bourbon (1 eps)
Adam Amara
Francis de Guise (1 eps)
Louis Pencréac'h
Charles de Lorraine (1 eps)