Kyla Pratt
Penny Proud (voice) (20 eps)
Tommy Davidson
Oscar Proud (voice) (20 eps)
Paula Jai Parker
Trudy Parker-Proud (voice) (20 eps)
Jo Marie Payton
Suga Mama Proud (voice) (20 eps)
Karen Malina White
Dijonay Jones (voice) (20 eps)
Soleil Moon Frye
Zoey Howzer (voice) (20 eps)
Alisa Reyes
LaCienega Boulevardez (voice) (20 eps)
Keke Palmer
Maya (voice) (10 eps)
A Boogie Wit Da Hoodie
KG (voice) (10 eps)
EJ Johnson
Michael (10 eps)
Cree Summer
Peabo (voice) (3 eps)
Alvaro Guttierez
Papi (voice) (3 eps)
Carlos Mencia
Felix (voice) (3 eps)
Kevin Michael Richardson
Doctor Payne (voice) / Papi Laugh (voice) (3 eps)
Patricia Belcher
Principal Hightower (voice) (3 eps)
Zachary Quinto
Barry (voice) (3 eps)
Asante Blackk
Kareem (voice) (3 eps)
Bresha Webb
CeCe (voice) (3 eps)
Aldis Hodge
Frankie (voice) (2 eps)
Carlos Alazraqui
Puff (voice) / Mr. Chips (voice) (2 eps)
Aiden Dodson
Bebe (voice) (2 eps)
Marcus T. Paulk
10-Year-Old Charles (voice) (2 eps)
Maria Canals-Barrera
Sunset (voice) (2 eps)
Billy Porter
Randall (voice) (2 eps)
Brenda Song
Vanessa Vue (voice) (2 eps)
Lizzo
Lizzo (voice) (1 eps)
Tiffany Haddish
Ms. Hill (voice) (1 eps)
Cee Lo Green
Shuggie (voice) (1 eps)
Bretman Rock
Makeup Boy (voice) (1 eps)
Sierra Ne Shelle Watson
Pink-I (voice) (1 eps)
Tone Loc
Penny's Singing Voice (voice) (1 eps)
Bridgette Bryant
Trudy as Minnie Ripperton (voice) (1 eps)
Rob Riggle
Rob Riggle (voice) (1 eps)
Marsai Martin
Iyanna (voice) (1 eps)
Arturo Castro
Neato Tito (voice) (1 eps)
Aries Spears
Sir Paid-a-Lot (voice) (1 eps)
Lamorne Morris
Lamorne Morris (voice) (1 eps)
Logan Browning
College Penny (voice) (1 eps)
Lena Waithe
College Maya (voice) (1 eps)
Karrie Martin Lachney
College LaCienega (voice) (1 eps)
Jeremy O. Harris
College Michael (voice) (1 eps)
Holly Winter
College Zoey (voice) (1 eps)
Desus Nice
College KG (voice) (1 eps)
Lil Nas X
June Bug (voice) (1 eps)
Princess Nokia
LaBrea (voice) (1 eps)
Tina Knowles
Ms. Gina (voice) (1 eps)
Kid Capri
Kid Capri (voice) (1 eps)
Eva Longoria
Melrose (voice) (1 eps)
Art Evans
Charlie (voice) (1 eps)
Debbie Allen
Myrtle (voice) (1 eps)
D.C. Young Fly
Man-Man (voice) (1 eps)
Dominique Fishback
12-Year-Old Suga Mama (voice) (1 eps)
Glynn Turman
Pa (voice) (1 eps)
James Pickens Jr.
Charles (voice) (1 eps)
Lawrence Hilton-Jacobs
Chuck (voice) (1 eps)
Kimberly Brooks
Harriet (voice) (1 eps)