Cathy Cavadini
Blossom (voice) (18 eps)
Tara Strong
Bubbles (voice) (18 eps)
Elizabeth Daily
Buttercup (voice) (18 eps)
Tom Kenny
Mayor / Snake / Lil' Arturo / Narrator (voice) (18 eps)
Tom Kane
Professor Utonium / Him / Talking Dog (voice) (18 eps)
Roger L. Jackson
Mojo Jojo (voice) (18 eps)
Jennifer Martin
Ms. Sara Bellum (voice) (18 eps)
Jennifer Hale
Ms. Keane / Princess Morbucks / Sedusa (voice) (18 eps)
Jim Cummings
Fuzzy Lumpkins (voice) (18 eps)
Jeff Bennett
Ace / Grubber / Big Billy (voice) (18 eps)
Chuck McCann
The Amoeba Boys (voice) (18 eps)
June Foray
Madame Argentina (voice) (1 eps)