Fran Drescher
Fran Fine (145 eps)
Charles Shaughnessy
Maxwell Sheffield (145 eps)
Daniel Davis
Niles (145 eps)
Lauren Lane
C.C. Babcock (145 eps)
Nicholle Tom
Margaret Sheffield (145 eps)
Benjamin Salisbury
Brighton Sheffield (145 eps)
Madeline Zima
Grace Sheffield (145 eps)
Rachel Chagall
Val Toriello (68 eps)
Renée Taylor
Sylvia Fine (64 eps)
Ann Morgan Guilbert
Yetta Rosenberg (54 eps)
Chester Drescher
Chester Babcock (uncredited) (9 eps)
Nora Dunn
Dr. Reynolds (7 eps)
Morty Drescher
Uncle Stanley (6 eps)
Ray Charles
Sammy (4 eps)
Andrew Levitas
Michael (4 eps)
Lawrence Mandley
Orderly (4 eps)
Sylvia Drescher
Female Patient (uncredited) (4 eps)
Zack Norman
Uncle Jack (3 eps)
DeeDee Rescher
Dottie (3 eps)
Roger Clinton, Jr.
Roger Clinton (3 eps)
Steve Lawrence
Morty Fine (3 eps)
Daniel Eric Fishbach
Marcus (uncredited) (3 eps)
Peter Marc Jacobson
Man Exiting Restroom with Fly Open (uncredited) (3 eps)
Lainie Kazan
Aunt Freida (2 eps)
Lorne Michaels
Barbra Streisand (2 eps)
Ron Melendez
Peter Bidwell (2 eps)
Sophie Ward
Jocelyn Sheffield (2 eps)
Gregg Rogell
Kenny Keroucan (2 eps)
Irene Olga López
Lupe (2 eps)
James Marsden
Eddie (2 eps)
Nancy Frangione
Marsha (2 eps)
Coolio
Coolio (2 eps)
Magda Harout
Sarah (2 eps)
Rita Rudner
Margot (2 eps)
Adeline Drescher
Addie (2 eps)
Dorothy Lyman
Dr. Quinn Director (voice) (uncredited) (2 eps)
Jonathan Penner
Danny Imperiali (2 eps)
Joseph Bologna
Dr. Joe Razzo (2 eps)
Roz Kern
Nurse (2 eps)
Allan Rich
The Judge (2 eps)
Rochelle Bond
Pamela (2 eps)
Fred Stoller
Fred, the pharmacist (2 eps)
Nancy Cassaro
Libby (2 eps)
Pamela Anderson
Heather Biblow-Imperiali (2 eps)
Whoopi Goldberg
Edna (2 eps)
J.D. Daniels
Jack Walker (2 eps)
Elizabeth Taylor
Herself (2 eps)
Céline Dion
Celine Dion (1 eps)
John Davidson
John Davidson (1 eps)
Joyce Brothers
Dr. Joyce Brothers (1 eps)
Michael McKean
Professor Noel Babcock PhD (1 eps)
Dina Merrill
Elizabeth Sheffield (1 eps)
Jane Seymour
Jane Seymour (1 eps)
Blanche Rubin
Old Lady (1 eps)
Victoria Hulett
Model (1 eps)
Ian Buchanan
Jules Kimball (1 eps)
Burt Bacharach
Burt Bacharach (1 eps)
Corbin Bernsen
Glen Mitchell (1 eps)
Roger Kern
Raymond Turnboat (1 eps)
Catherine Oxenberg
Sydney Mercer (1 eps)
Donna Dixon
Monica Baker (1 eps)
Derek Webster
Reporter (1 eps)
Harry Hamlin
Professor Steve (1 eps)
Donna Douglas
Donna Douglas (1 eps)
Efrem Zimbalist Jr.
Theodore Timmons (1 eps)
Burke Moses
Tony Tatorri (1 eps)
Liz Smith
Liz Smith (1 eps)
Brenda Ballard
Woman At The Park (1 eps)
Bryan Kirkwood
Maggie's Boyfriend (1 eps)
Steve Blackwood
Doctor (1 eps)
Diane Baker
Roberta (1 eps)
Alex Sternin
Trick-or-Treater (1 eps)
Anthony Cistaro
Carlo (1 eps)
Candy Trabuco
Lexine (1 eps)
Dayton Callie
The Sergeant (1 eps)
Billy Ray Cyrus
Billy Ray Cyrus (1 eps)
Brian George
Butler Inspector (1 eps)
Eric Braeden
Frank Bradley (1 eps)
Myles Sheridan
Brighton's Friend (1 eps)
Marvin Hamlisch
Alan Neider (1 eps)
Paolo Seganti
Philippe (1 eps)
Mark Chaet
Hotel Valet (1 eps)
Anne Lambton
Madeline Porter (1 eps)
Linda Shayne
Singer (1 eps)
Ron Greschner
Ron Greschner (1 eps)
Lila Garrett
Lady in Ladies' Room (1 eps)
Thomas Dekker
J.B. Bingington's Son (1 eps)
Gerry McIntyre
Orderly (1 eps)
Gloria Gifford
INS Officer (1 eps)
Judith Hoag
Kathy Marie O'Malley / Katherine Porter (1 eps)
Honey Lauren
Waitress (1 eps)
Gabriel Bologna
Dr. Taylor (1 eps)
Laurelyn Scharkey
Showgirl Gigi (1 eps)
Cristine Rose
Dr. Voort (1 eps)
Peggy Blow
Nanny (1 eps)
Rosie O'Donnell
Cozette (1 eps)
Wallace Shawn
Charles Haste (1 eps)
Leigh Lawson
Lester (1 eps)
Benjamin Kimball Smith
Brighton's Friend (1 eps)
Wayne C. Dvorak
Waiter (1 eps)
Alex Trebek
Alex Trebek (1 eps)
Milton Berle
Uncle Manny (1 eps)
Philip Casnoff
Cantor Gary Isaacs (1 eps)
Ray Abruzzo
Chopper Pilot (1 eps)
Dakin Matthews
Dean Sterrett (1 eps)
Howie Mandel
Howie Mandel (1 eps)
Jason Andrews
Guard (1 eps)
Sam Mountain
Andrew Lloyd Webber (1 eps)
Robert Lee Jacobs
Blake Glickman (1 eps)
David Letterman
David Letterman (uncredited) (1 eps)
Alex Nevil
Mugger (1 eps)
Ron Orbach
Barry Cooperman (1 eps)
Kort Falkenberg
Priest (1 eps)
Jeff Mooring
Waiter (1 eps)
Wilder Shaw
Trick-or-Treater (1 eps)
Tracy Kolis
Leslie (1 eps)
Gabrielle Boni
Erica (1 eps)
Scott Whyte
Sean (1 eps)
Curtis Hood
Investor Man (1 eps)
Bob Goen
Bob Goen (1 eps)
John Muntner
Delivery Guy (1 eps)
Barbara Howard
Fertility Doctor (1 eps)
Richard Kind
Jeffrey Needleman (1 eps)
Richard Portnow
Phillipe (1 eps)
Ian Abercrombie
Butler Inspector (1 eps)
Nick Salamone
Reporter (1 eps)
Christopher Winfield
Father Joffrey (1 eps)
Charlie Newmark
Dr. Hamilton (1 eps)
Tim Lounibos
Mark (1 eps)
Jasmin Beto
Hungry Model (1 eps)
James McDonnell
Colin (1 eps)
Edward Penn
Richard Porter (1 eps)
Ralph Manza
Saul (1 eps)
Blake McIver Ewing
Robby (1 eps)
Martha Gehman
Betty (1 eps)
Jackie Tohn
Tiffany Koenig (1 eps)
Lane Davies
Nigel Waters (1 eps)
Sally Jessy Raphael
Sally Jessy Raphael (1 eps)
Christopher Rich
Kurt Jacobs (1 eps)
Liza Stanley
Reporter (1 eps)
Ofir Anschel
Yossi (1 eps)
William Bumiller
Detective Schoenfeld (1 eps)
Jennifer Ingersoll
Cecily (1 eps)
Shari Shaw
Delivery Nurse (1 eps)
Margaret Cho
Caryn (1 eps)
Ellen Ratner
Nadine Cooperman (1 eps)
Shari Lewis
Shari Lewis (1 eps)
Louis Guss
Irving Koenig (1 eps)
Aaron Heyman
Man at the Movie (1 eps)
Morgan Brittany
Judy Silverman (1 eps)
Andy Dick
Pepé / Bernie (1 eps)
Matt McCoy
Steve Mintz (1 eps)
Patti LaBelle
Patti LaBelle (1 eps)
Bob Barker
Bob Barker (1 eps)
Tyne Daly
Mona (1 eps)
Jack Knight
Doorman (1 eps)
Michael Winters
Doug Emerson (1 eps)
Ray Stricklyn
Wendell Kent (1 eps)
Burke Roberts
Photographer (1 eps)
Charley Geary
Singer (1 eps)
Maxwell Caulfield
Rodney Pembroke (1 eps)
Jake Richardson
Willie (1 eps)
Miriam Flynn
Country Club Manager (1 eps)
Heidi Thompson
The mysterious person in bandages (1 eps)
Tracy Nicole Kerestes
Student (1 eps)
Robert Culp
Stewart Babcock (1 eps)
Adam Hendershott
Kevin (1 eps)
Kellen Hathaway
Bernard (1 eps)
Bonnie Biehl
Heidi (1 eps)
George Murdock
Dakota Williams (1 eps)
Andy Mackenzie
Repairman (1 eps)
Anika Marinelli
The Prostitute (1 eps)
William Palmieri
Orderly (1 eps)
Ben Vereen
Ben Vereen (1 eps)
Esther Lapidus
Auditioner (1 eps)
Mijanou
Heidi's friend (1 eps)
Eydie Gormé
Eydie Gormé (1 eps)
Darryl Hickman
Priest (1 eps)
Twiggy
Jocelyn Sheffield (1 eps)
Nancy Linari
Mrs. Livingston (1 eps)
Stephen Nichols
Brock Storm (1 eps)
Lizzy Magill
Singer (1 eps)
Donna Cherry
(uncredited) (1 eps)
Marji Martin
Nanny Bower (1 eps)
Marion Ramsey
Woman in Audience (1 eps)
Chad Everett
Dr. Osborn (1 eps)
Preston Wamsley
Young Niles (1 eps)
Lauren Tom
Kim (1 eps)
Lu Leonard
Nanny (1 eps)
Danielle Dowdy
Security Guard in Hollywood (1 eps)
Lesley-Anne Down
Chloe Simpson (1 eps)
Dean Tarrolly
David Stavros (1 eps)
Steve Gideon
Singer (1 eps)
Jay Robinson
The Maitre'd (1 eps)
Lauren Koslow
C.C.'s Friend (1 eps)
Marilyn Cooper
Grandma Nettie (1 eps)
Nikki Cox
Cindy Wentworth (1 eps)
Marianne Muellerleile
Andrea's Mother (1 eps)
Sherman Augustus
Doorman (1 eps)
Dona Hardy
Sister (1 eps)
Timothy Watters
President Bill Clinton (1 eps)
Bonnie Morgan
Brooke (1 eps)
Nancy Lenehan
Russian Woman (1 eps)
Fritzi Burr
Woman at the Movie (1 eps)
Steven Anderson
Doctor (1 eps)
Tracy Nelson
Mary Ruth (1 eps)
Pamela Dillman
C.C.'s Friend (1 eps)
Heather Lynne Allen
Harpist (1 eps)
Allen Bloomfield
Uncle Myron (1 eps)
Miko Hughes
Frank Bradley Jr (1 eps)
Rita Moreno
Mrs. Wickervich Stone (1 eps)
Cloris Leachman
Clara Mueller (1 eps)
Scott Baldyga
Hotel Clerk (1 eps)
Lynn Redgrave
Lynn Redgrave (1 eps)
Caroline Rhea
Caroline Rhea (1 eps)
Chuck Mavich
Pizza Delivery Guy (1 eps)
Michael C. McCarthy
David (1 eps)
Erik Estrada
Erik Estrada (1 eps)
George Coe
Ernest (1 eps)
Maree Cheatham
Emma Trusdale (1 eps)
Lisa Alpert
Maid in 'Royal Flush' (1 eps)
Christina Pickles
Nurse (1 eps)
Marvin Nathan
Cousin Ira (1 eps)
Patrick Cassidy
Mr. Anthony (1 eps)
Barry Watson
Greg (uncredited) (1 eps)
Leann Hunley
Bobbi Jo (1 eps)
Francesca P. Roberts
Nurse Smith (1 eps)
Richard Roat
Santa Claus (1 eps)
Linda Harmon
Solo singer (voice) (uncredited) (1 eps)
Susan Krebs
Headmistress (1 eps)
Bruce Vilanch
Bruce Vilanch (1 eps)
Jamie Renée Smith
Young Fran Fine (1 eps)
Matthew Viera
College Applicant (1 eps)
Tawny Moyer
Nurse (1 eps)
Ellen Albertini Dow
Wendell Kent's Mother (uncredited) (1 eps)
Anne Betancourt
Doctor (1 eps)
Carol Channing
Carol Channing (1 eps)
Bob Clendenin
The Bum (1 eps)
Dan Aykroyd
Repair Man (uncredited) (1 eps)
Edward Hibbert
Claude (1 eps)
Monica Seles
Monica Seles (1 eps)
Marlo Jenee
Second Nanny (1 eps)
Pete Leal
Cleaning Man (1 eps)
Kimberly Natasha Ali
Patti's Daughter (1 eps)
Bess Armstrong
Sara Sheffield (uncredited) (1 eps)
Skyler Littlefield
Zachary Baker (1 eps)
Jared Doud
Richard (1 eps)
Mark Newsom
'Crab Cake' Waiter (uncredited) (1 eps)
Tom Bergeron
Tom Bergeron (1 eps)
Steve Posner
Car Dealer (1 eps)
Lorna Luft
Cousin Susan (1 eps)
Hal Linden
Maury Sherry (1 eps)
Amy Tolsky
Singer (1 eps)
Tacey Adams
Hollywood Squares Contestant (1 eps)
Teresa Barnwell
Hillary Clinton (uncredited) (1 eps)
Ryan McPartlin
Performer (1 eps)
Chris Bruno
Ski Instructor (1 eps)
Martin Mull
Martin Mull (1 eps)
Christopher Marquette
Young Maxwell Sheffield (1 eps)
Alissa Dowdy
Dunson Twin (1 eps)
Isaac Chernotsky
Steven Spielberg (1 eps)
Estelle Getty
Estelle Getty (1 eps)
Renee Cohen
Young Yetta (1 eps)
Joe Lando
Joe Lando (1 eps)
Chris Elliott
Chris Malley (1 eps)
Saemi Nakamura
Mrs. Fu (1 eps)
Helen Geller
Singer (1 eps)
Dennis Dun
Doctor Fu (1 eps)
Jennifer Edwards
Society Woman #2 (1 eps)
Jane Sibbett
Marcy Feldman / Morgan Faulkner (1 eps)
J. Madison Wright
Betty Jo (1 eps)
Roseanne Barr
Cousin Sheila (1 eps)
Elton John
Elton John (1 eps)
Chevy Chase
Chevy Chase (1 eps)
Jennie Kwan
Mai Ling (1 eps)
Michael Bolton
Michael Bolton (1 eps)
Scott Baio
Dr. Frankie Cresitelli (1 eps)
Joan Van Ark
Margo Lange (1 eps)
Marla Maples
Marla Maples (1 eps)
Roslyn Kind
Roslyn Kind (1 eps)
Tia Riebling
Mother in the Park (1 eps)
Peter Scolari
Leslie Tilbert (1 eps)
Joan Collins
Joan Sheffield (1 eps)
Robert Vaughn
James Sheffield (1 eps)
Donald O'Connor
Fred (1 eps)
Athena Ashburn
Chatterbox Cosmetologist (1 eps)
Anthony Addabbo
Mike LaVoe (1 eps)