John Turturro
William of Baskerville (8 eps)
Rupert Everett
Bernardo Gui (8 eps)
Damian Hardung
Adso of Melk (8 eps)
Fabrizio Bentivoglio
Remigio of Varagine (8 eps)
Tchéky Karyo
Pope John XXII (8 eps)
Greta Scarano
Anna / Margherita (8 eps)
Richard Sammel
Malachi of Hildesheim (8 eps)
Stefano Fresi
Salvatore of Montferrat (8 eps)
Roberto Herlitzka
Alinardo of Grottaferrata (8 eps)
Fausto Maria Sciarappa
Nicola of Morimondo (8 eps)
Antonia Fotaras
The Occitan Girl (8 eps)
Benjamin Stender
Benno of Uppsala (8 eps)
Claudio Bigagli
Gerolamo of Caffa (8 eps)
Corrado Invernizzi
Michele of Cesena (8 eps)
Max Malatesta
Aymaro of Alessandria (8 eps)
James Cosmo
Jorge of Burgos (8 eps)
Michael Emerson
Abo of Fossanova - The Abbot (8 eps)
Rinat Khismatouline
Cardinal du Pouget (8 eps)
David Brandon
Hugh of Newcastle (8 eps)
Peter Davison
Old Adso / Narrator (voice) (8 eps)
Sebastian Koch
Baron of Neuenberg (2 eps)
Leonardo Pazzagli
Adelmo of Otranto (2 eps)
Diego Delpiano
Martino (1 eps)