Lily Tomlin
Ms. Frizzle (voice) (13 eps)
Daniel DeSanto
Carlos (voice) (13 eps)
Stuart Stone
Ralphie (voice) (13 eps)
Erica Luttrell
Keesha (voice) (13 eps)
Danny Tamberelli
Arnold (voice) (13 eps)
Andre Ottley-Lorant
Tim (voice) (13 eps)
Tara Meyer
Dorothy Ann (voice) (13 eps)
Maia Filar
Phoebe (voice) (13 eps)
Malcolm-Jamal Warner
The Producer (13 eps)