Lily Tomlin
Ms. Frizzle (voice) (13 eps)
Daniel DeSanto
Carlos (voice) (13 eps)
Stuart Stone
Ralphie (voice) (13 eps)
Erica Luttrell
Keesha (voice) (13 eps)
Tara Meyer
Dorothy Ann (voice) (13 eps)
Maia Filar
Phoebe (voice) (13 eps)
Malcolm-Jamal Warner
The Producer (13 eps)
Max Beckford
Tim (voice) (13 eps)
Amos Crawley
Arnold (voice) (13 eps)
Dom DeLuise
Baker (1 eps)
Tyne Daly
Ralphie's Mom (1 eps)