Lily Tomlin
Ms. Frizzle (voice) (52 eps)
Daniel DeSanto
Carlos (voice) (52 eps)
Stuart Stone
Ralphie (voice) (52 eps)
Erica Luttrell
Keesha (voice) (52 eps)
Tara Meyer
Dorothy Ann (voice) (52 eps)
Maia Filar
Phoebe (voice) (52 eps)
Malcolm-Jamal Warner
The Producer (52 eps)
Danny Tamberelli
Arnold (voice) (39 eps)
Andre Ottley-Lorant
Tim (voice) (39 eps)
Lisa Yamanaka
Wanda (voice) (13 eps)
Max Beckford
Tim (voice) (13 eps)
Amos Crawley
Arnold (voice) (13 eps)
Paul Winfield
(voice) (4 eps)
Tyne Daly
(voice) (2 eps)
Rosalind Chao
Mrs. Li (voice) (2 eps)
Elliott Gould
(voice) (1 eps)
Dana Elcar
(voice) (1 eps)
Dom DeLuise
Baker (1 eps)
Sherman Hemsley
Mr. Junkett (voice) (1 eps)
Ed Asner
(voice) (1 eps)
Alex Trebek
(voice) (1 eps)
Michael York
(voice) (1 eps)
Eartha Kitt
Mrs. Franklin (1 eps)
Edward James Olmos
(voice) (1 eps)
Robby Benson
(voice) (1 eps)
Ed Begley Jr.
(voice) (1 eps)
Matt Frewer
(voice) (1 eps)
Jessica Walter
(voice) (1 eps)
Dolly Parton
(voice) (1 eps)
Wynonna Judd
Molly Cule (voice) (1 eps)
Dabney Coleman
(voice) (1 eps)
Bebe Neuwirth
(voice) (1 eps)
Malcolm McDowell
(voice) (1 eps)
Dan Marino
(voice) (1 eps)
Cindy Williams
Gerri Poveri (voice) (1 eps)
Swoosie Kurtz
(voice) (1 eps)
Rita Moreno
(voice) (1 eps)
Tony Randall
(voice) (1 eps)