Jennifer Beals
Bette Porter (13 eps)
Katherine Moennig
Shane McCutcheon (13 eps)
Mia Kirshner
Jenny Schecter (13 eps)
Erin Daniels
Dana Fairbanks (13 eps)
Leisha Hailey
Alice Pieszecki (13 eps)
Laurel Holloman
Tina Kennard (13 eps)
Pam Grier
Kit Porter (13 eps)
Sarah Shahi
Carmen de la Pica Morales (13 eps)
Rachel Shelley
Helena Peabody (13 eps)
Eric Lively
Mark Wayland (13 eps)
Sandra Bernhard
Charlotte Birch (5 eps)
Cobie Smulders
Leigh Ostin (4 eps)
Charles S. Dutton
Dr. Benjamin Bradshaw (4 eps)
Camryn Manheim
Veronica Bloom (4 eps)
Chris William Martin
Hunter Kirby (4 eps)
Melissa Leo
Winnie Mann (3 eps)
Jane Lynch
Joyce Wischnia (3 eps)
Kelly Lynch
Ivan Aycock (3 eps)
Lauren Lee Smith
Lara Perkins (3 eps)
Ossie Davis
Melvin Porter (3 eps)
Judith Maxie
Dr. Wilson (3 eps)
Anne Ramsay
Robin (2 eps)
Sara Botsford
Allen Barnes (2 eps)
Tony Goldwyn
Burr Connor (2 eps)
Holland Taylor
Peggy Peabody (2 eps)
Mimi Kuzyk
Isabel (1 eps)
Tygh Runyan
Gene Feinberg (1 eps)
Guinevere Turner
Gabby Deveaux (1 eps)
Gloria Steinem
Self (1 eps)
Katy Selverstone
Phoebe Sparkle (1 eps)
Derek de Lint
Manfredi Ferrer (1 eps)
Arianna Huffington
Self (1 eps)
Ion Overman
Candace Jewell (1 eps)
Holly Ferguson
Claudia (1 eps)
Stacy Fair
Nora (1 eps)
Melissa Rivers
Self (1 eps)