Clive Owen
Dr. John Thackery (20 eps)
André Holland
Dr. Algernon Edwards (20 eps)
Jeremy Bobb
Herman Barrow (20 eps)
Juliet Rylance
Cornelia Robertson (20 eps)
Eve Hewson
Lucy Elkins (20 eps)
Michael Angarano
Dr. Bertram “Bertie" Chickering, Jr. (20 eps)
Cara Seymour
Sister Harriet (20 eps)
Eric Johnson
Dr. Everett Gallinger (20 eps)
Chris Sullivan
Tom Cleary (20 eps)
Ying Ying Li
Lin-Lin (9 eps)
Zuzanna Szadkowski
Nurse Pell (7 eps)
Grainger Hines
Captain August Robertson (5 eps)
Leon Addison Brown
Jesse Edwards (5 eps)
Lucas Papaelias
Eldon Pouncey (5 eps)
Suzanne Savoy
Victoria Robertson (5 eps)
Maya Kazan
Eleanor Gallinger (5 eps)
Danny Hoch
Bunky Collier (4 eps)
LaTonya Borsay
Mrs. Edwards (4 eps)
Happy Anderson
Jimmy (4 eps)
David Fierro
Inspector Jacob Speight (4 eps)
Rachel Korine
Junia (3 eps)
Frank Wood
Mr. Havershorn (3 eps)
Michael Berresse
Parke Davis Rep. (3 eps)
Melissa Errico
Catherine Christiansen (3 eps)
Collin Meath
Phinny Sears (3 eps)
Emily Bergl
Mrs. Hemming (3 eps)
Rob Michael Hugel
Mr. Gatchell (3 eps)
Emily Kinney
Nurse Daisy Ryan (3 eps)
Perry Yung
Ping Wu (2 eps)
Reg Rogers
Dr. Bertram Chickering, Sr. (2 eps)
Kim Rideout
Cornelia's Maid (2 eps)
Tom Lipinski
Phillip Showalter (2 eps)
Gary Simpson
Hobart Showalter (2 eps)
Molly Price
Effie Barrow (2 eps)
Richard James Porter
Monsignor Joseph Mills Lawlor (2 eps)
Johanna Day
Eunice Showalter (2 eps)
Matt Frewer
Dr. J.M. Christiansen (2 eps)
Cait Cortelyou
Nurse Monk (2 eps)
Victoria Leigh
Cora Hemming (2 eps)
Pei Pei Lin
Chinese Prostitute (2 eps)
Jennifer Ferrin
Abigail Alford (2 eps)
Ylfa Edelstein
Nurse Baker (2 eps)
Makenzie Leigh
Amy O'Connor (2 eps)
Hamilton Bonita
Mrs.Gamble (2 eps)
Melanie Brook
Frances (2 eps)
Tom Papa
Luff (1 eps)
Rachel Izen
Nurse Braun (1 eps)
Michael Nathanson
Dr. Levi Zinberg (1 eps)
John Hodgman
Doctor Entrusted with Eleanor (1 eps)
Noelle P. Wilson
Cromartie Nurse (1 eps)
Alfred Cole
Prize Fighter (1 eps)
David Wilson Barnes
Dr. Hackett (1 eps)
Charles Aitken
Cornelia's Brother (1 eps)
Christian Kauffmann
Minister (1 eps)
Mandi Madsen
Joella (1 eps)
Karl Bury
Mr. Corker (1 eps)
Kate Easton
Mrs. Warren (1 eps)
Louis Butelli
Mr. Gentile (1 eps)
Christopher Dalbey
Bleier Driver (1 eps)
Lucy Jurevics
Yetta Krawetz (1 eps)
Aija Terauda
Mrs. Krawetz (1 eps)
Mārtiņš Straupe
Mr. Krawetz (1 eps)
Caitlin McDonough-Thayer
Miss Telfer (1 eps)
Monty Stuart
Pete (1 eps)
Zenon Zeleniuch
Slum Landlord (1 eps)
Rob Morgan
Diggs Man (1 eps)
Andy Murray
Clarence Mulkeen (1 eps)
Bridget Barkan
Nora (1 eps)
Christopher Clark Gates
Dr. Lyons (1 eps)
Ashley Bryant
Infirmary Nurse (1 eps)
David Neal Levin
Mr. Olynyk (1 eps)
Ryan Homchick
Orderly Schleif (1 eps)
Dean Neistat
McCarthy (1 eps)
Erika Rolfsrud
Edwards' Patient's Mother (1 eps)
Pernell Walker
Ida Harris (1 eps)
Antwayn Hopper
Woodson (1 eps)
Adam Mucci
Dietz (1 eps)
Craig muMs Grant
Hernia Patient (1 eps)
Brian Tyree Henry
Larkin (1 eps)
Lily Brahms
Clara Chickering (1 eps)
Phillip Chorba
Quinn (1 eps)
Clarke Thorell
McTeague (1 eps)
Tom Treadwell
Mr. Edison (1 eps)
Maja Wampuszyc
Mrs. Zygmund (1 eps)
Jon Patrick Walker
Doctor at Orphanage (1 eps)
David Tichy
Rat Catcher (1 eps)
Helen Coxe
Miss Carhart (1 eps)
Brian Kerwin
Corky (1 eps)
Peter Maloney
Barber / Doc (1 eps)
Edwin Lugo
Ernesto Mendieta (1 eps)
Ghana Leigh
Miss Odom (1 eps)
Erin Wilhelmi
Lottie (1 eps)
David T. Zimmerman
Inspector Bradley (1 eps)
Athan Sporek
Paulo (Street Urchin) (1 eps)
Henry Gagliardi
Krawetz Kid (uncredited) (1 eps)
Sawyer Barth
The Whispering Kid (1 eps)
Dominique Fishback
Black Girl (1 eps)
Danya LaBelle
Mrs. Lefkowitz (1 eps)
Arielle Goldman
Genevieve Everidge (1 eps)
Jonah Coppolelli
Paper Boy, Working Class Boy (1 eps)