Eartha Kitt
Yzma (voice) (91 eps)
Curtis Armstrong
Mr. Moleguaco (voice) (90 eps)
Justin Cowden
Guaca (voice) (90 eps)
Rip Taylor
The Royal Record Keeper (voice) (90 eps)
Shane Baumel
Tipo (voice) (90 eps)
Bob Bergen
Bucky (voice) (90 eps)
J.P. Manoux
Kuzco (voice) (90 eps)
Patrick Warburton
Kronk (voice) (90 eps)
Jessica DiCicco
Malina (voice) (90 eps)
John Goodman
Pacha (voice) (57 eps)
Fred Tatasciore
Pacha (voice) (33 eps)
Miley Cyrus
Mudka's Meat Hut Waitress (voice) (6 eps)
Candi Milo
Ms. Oopatral (voice) (4 eps)
Frank Welker
Creepy Old Man / Skeleton Anteater (voice) (2 eps)
Brenda Song
Dancing Queen (voice) (1 eps)
Cole Sprouse
Zim (voice) (1 eps)
Gabriel Iglesias
Yu / Tu (voice; uncredited) (1 eps)
Kevin Michael Richardson
Kavo (voice; uncredited) (1 eps)
Patti Deutsch
Mata (voice) (1 eps)
Tress MacNeille
Mrs. Upachal (voice) (1 eps)
Tom Kenny
Narrator (voice) (1 eps)
Courtney Peldon
Cuxi / Curi / Cuca (voice) (1 eps)
Michaela Jill Murphy
Chaca (voice) (1 eps)
Mark Schiff
Urkon (voice) (1 eps)
Jeff Bennett
Topo / Ipi (voice) (1 eps)