Jeremy Irons
Rodrigo Borgia (29 eps)
François Arnaud
Cesare Borgia (29 eps)
Holliday Grainger
Lucrezia Borgia (29 eps)
Joanne Whalley
Vanozza Cattaneo (29 eps)
Sean Harris
Micheletto (29 eps)
Vernon Dobtcheff
Cardinal Versucci (21 eps)
Colm Feore
Giuliano Della Rovere (20 eps)
Peter Sullivan
Cardinal Ascanio Sforza (20 eps)
Lotte Verbeek
Giulia Farnese (20 eps)
David Oakes
Juan Borgia (11 eps)
Thure Lindhardt
Rufio (10 eps)
Joseph Macnab
Prospero Colonna (10 eps)
Luke Pasqualino
Paolo (7 eps)
Aidan Alexander
Gioffre Borgia (5 eps)
Ivan Kaye
Ludovico Sforza (4 eps)
Emmanuelle Chriqui
Sancia (3 eps)
Helen Bradbury
Nanny (3 eps)
Giacomo Gonnella
Battista Colonna (2 eps)
Gados Béla
Il Cerimoniere (2 eps)
Tom Keller
Gamaliel (2 eps)
Jonah Russell
Cardinal Petrucci (2 eps)
Russ Bain
French Soldier 1 (1 eps)
Richard Rifkin
The Penitent (1 eps)
Luke Allen-Gale
Fredirigo (1 eps)
Prometheus Aleifer
Roberto Orsini (1 eps)
Pilou Asbæk
Paolo Orsini (1 eps)
Callum Turner
Calvino (1 eps)
Barney Glover
Vincenzo Salvatore (1 eps)
Jamie Beamish
Siege Overseer (1 eps)
Kata Sarbó
Nurse 2 (1 eps)
Elyes Gabel
Cem Sultan (1 eps)
Arkie Reece
French Rider (1 eps)
