Jared Padalecki
Sam Winchester (22 eps)
Jensen Ackles
Dean Winchester (22 eps)
Genevieve Padalecki
Ruby (11 eps)
Jim Beaver
Bobby Singer (7 eps)
Julie McNiven
Anna Milton (5 eps)
Robert Wisdom
Uriel (4 eps)
Christopher Heyerdahl
Alastair (3 eps)
Kurt Fuller
Zachariah (3 eps)
Traci Dinwiddie
Pamela Barnes (3 eps)
Katherine Boecher
Lilith (2 eps)
Colin Ford
Young Sam Winchester (2 eps)
Juliana Wimbles
Demon Nurse (2 eps)
Cainan Wiebe
Bully #1 (2 eps)
Mark Rolston
Alastair (2 eps)
A.J. Buckley
Ed Zeddmore (1 eps)
Travis Wester
Harry Spangler (1 eps)
Nicki Aycox
Meg Masters (1 eps)
Matt Cohen
Young John Winchester (1 eps)
Rob LaBelle
Father Lehne (1 eps)
Darren Dolynski
Lilith's Demon (1 eps)
Artine Brown
Night Watchman (1 eps)
Kirsten Kilburn
Nun (1 eps)
Joey Bothwell
Nurse (1 eps)
Wynn Everett
Amelia Novak (1 eps)
Sydney Imbeau
Claire Novak (1 eps)
Dedee Pfeiffer
Kate Milligan (1 eps)
Aaron Pearl
Roger (1 eps)
Heather Feeney
Lisa Barton (1 eps)
Linnea Sharples
Lisa (1 eps)
Keegan Connor Tracy
Sera Siege (1 eps)
Michael Puttonen
Cemetery Director (1 eps)
Michael P. Northey
Comic Book Store Owner (1 eps)
Eby Luking
Denise (1 eps)
Mike Klemak
Cop (1 eps)
Terri O'Neill
Waitress (1 eps)
Jack Plotnick
Ian (1 eps)
Megan Leitch
Mother (1 eps)
Richard Side
Paul Dunbar (1 eps)
Reilly Kiff
Daughter (1 eps)
John Hainsworth
P.T. Sandover (1 eps)
David Milchard
Dean's Co-Worker (1 eps)
Steve Elliott
Victim (1 eps)
Brian McCaig
Security Guard (1 eps)
Alexander Gould
Cole Griffith (1 eps)
Mike Dopud
Jim Jenkins (1 eps)
Brent Woolsey
Cop (1 eps)
Andrew Wheeler
Groundskeeper (1 eps)
Crystell Hendricks
Angel (1 eps)
Viv Leacock
Pete Hensley (1 eps)
Maya Massar
Mara Griffith (1 eps)
Gabriel Carter
Shooter (1 eps)
John Burnside
Jacob (1 eps)
Maïté Schwartz
Cara Roberts (1 eps)
Phillip Mitchell
Demon #1 (1 eps)
Jim Parrack
Nick Monroe (1 eps)
Kristian Haas
Demon #2 (1 eps)
Mark Hildreth
Adam Benson (1 eps)
Tosha Doiron
Vicki Benson (1 eps)
Lawrence Haegert
Lenny Bristol (1 eps)
Brock Kelly
Young Dean Winchester (1 eps)
Moneca Delain
Belle (1 eps)
Candice King
Amanda Heckerling (1 eps)
Fulvio Cecere
Honey Wagon Owner (1 eps)
Chad Willett
Mr. Wyatt (1 eps)
Brandi Alexander
Stripper (1 eps)
Tim Henry
Dirk MacGregor, Sr. (1 eps)
Chris Baker
Siren (1 eps)
Casey Dubois
Dirk MacGregor, Jr. (1 eps)
Adam MacDougall
Fight Teacher (1 eps)
Jenna Romanin
Closet Make-Out Girl (1 eps)
Barry Bostwick
Jay (1 eps)
Eileen Barrett
Young Dean's Teacher (1 eps)
Luke Camilleri
Jeb Dexter (1 eps)
Hayley Saulnier
April Dawkins (1 eps)
Reilly Dolman
Lunchroom Jock (1 eps)
Helen Slater
Susan Carter (1 eps)
John Rubinstein
Charlie (1 eps)
Adam Kennedy
Aaron Branson (1 eps)
David Newsom
Brian Carter (1 eps)
Michael Weston
Young Charlie (1 eps)
Bradley Stryker
Uncle Ted (1 eps)
Alex Zahara
Patrick Vance (1 eps)
Alexa Nikolas
Kate Carter (1 eps)
Amber Lewis
Vance's Assistant (1 eps)
Dylan Minnette
Danny Carter (1 eps)
Ecstasia Sanders
Maddie (1 eps)
Mandy Playdon
Lizzie Gibson (1 eps)
Jordan Becker
Jason (1 eps)
Gerry Rousseau
Bill Gibson (1 eps)
Chris Burns
Chief (1 eps)
Gwynyth Walsh
Psychologist (1 eps)
Mark Sweatman
Lizzie's Brother (1 eps)
Anna Williams
Blonde Ruby (1 eps)
Karin Konoval
Mrs. Curry (1 eps)
Drew Nelson
Crossroads Demon (1 eps)
Anita Brown
Hope Lynn Casey (1 eps)
Dave Collette
Orderly Demon (1 eps)
Ted Raimi
Wesley Mondale (1 eps)
Shawn Hall
Pool Player (1 eps)
Tseng Chang
Lucky Chin's Owner (1 eps)
Samantha Page
Little Girl (1 eps)
Nicole Leduc
Audrey Elmer (1 eps)
Michelle Hewitt-Williams
Maid Ruby (1 eps)
Barbara Kottmeier
Candace Armstrong (1 eps)
Anthony Harrison
Doctor (1 eps)
Calum Worthy
Denny (1 eps)
Chad Krowchuk
Waiter (1 eps)
Ryan Grantham
Todd (1 eps)
Michael Teigen
Teddy (1 eps)
Sean Devine
Gus (1 eps)
Don McManus
Don Harding (1 eps)
Noel Johansen
Hal (1 eps)
Ashley Benson
Tracy Davis (1 eps)
Kirsten Robek
Mrs. Wallace (1 eps)
Talon Dunbar
Bully #2 (1 eps)
Jean-Luc Bilodeau
Justin (1 eps)
Luisa d'Oliveira
Jenny (1 eps)
David Ingram
Luke Wallace (1 eps)
Alex Robertson
Astronaut Kid (1 eps)
Sierra McCormick
Lilith (1 eps)
Jack Conley
Al Britton (1 eps)
Steph DuVall
Jack Garland (1 eps)
David Mattey
Luther Garland (1 eps)
Jerry Wasserman
Coroner (1 eps)
Darcy Cadman
Deputy Linus (1 eps)
Michael Roberds
Mark Hutchins (1 eps)
Brady Schlecker
Frank O'Brien (1 eps)
Darren Daurie
Frank's Buddy #1 (1 eps)
Wade Fennig
Frank's Buddy #2 (1 eps)
Todd Stashwick
Dracula (1 eps)
Dameon Clarke
Jack Montgomery (1 eps)
Melinda Sward
Jamie (1 eps)
Allison Hossack
Deanna Campbell (1 eps)
Joanne Kelly
Michelle Montgomery (1 eps)
Holly Dignard
Lucy (1 eps)
Ron Lea
Travis (1 eps)
Christopher B. MacCabe
Dr. Brown (1 eps)
Michael Eklund
Ed Brewer (1 eps)
Ken Camroux-Taylor
Mr. D (1 eps)
Craig Stanghetta
Bartender (1 eps)
Garry Chalk
Sheriff Deitrich (1 eps)
Angelique Naude
Girl in Bar (1 eps)
Troy Anthony Young
Daniel Elkins (1 eps)
Todd Scott
Security Guard (1 eps)
Andy Nez
Cop (1 eps)
Colby Wilson
Guy in Bar (1 eps)
Carmen Lavigne
Anne Marie (1 eps)
Marcus Hondro
Captive Demon (1 eps)
Mark McConchie
Used Car Salesman (1 eps)
Jason Poulsen
Rick Deacon (1 eps)
Nadine Wright
Beth Whitshire (1 eps)
John Stewart
Museum Security Guard (1 eps)
Max Lloyd-Jones
Charlie Whitshire (1 eps)
Giacomo Baessato
Pizza Delivery Guy (1 eps)
Charles Malik Whitfield
Victor Henriksen (1 eps)
Chris Gauthier
Ronald Reznick (1 eps)
Audra Ricketts
Olivia Lowry (1 eps)
Daniel Arnold
Ghostly Man (1 eps)
Eve Casha
Ghost Twin #1 (1 eps)
Scott Parsons
Diner Patron Demon (1 eps)
Lara Casha
Ghost Twin #2 (1 eps)
Jen Halley
Demon Waitress (1 eps)
Krista Mitchell
Ghostly Woman (1 eps)
Marc Gaudet
Fry Cook Demon (1 eps)
Lindsey McKeon
Tessa (1 eps)
Mitch Pileggi
Samuel Campbell (1 eps)
Amy Gumenick
Mary Winchester (young) (1 eps)
Samantha Smith
Mary Winchester (1 eps)
Jake Abel
Adam Milligan / Michael (1 eps)