Frank Welker
Scooby-Doo / Fred Jones (voice) (59 eps)
Grey DeLisle
Daphne Blake (voice) (58 eps)
Mindy Cohn
Velma Dinkley (voice) (52 eps)
Matthew Lillard
Norville 'Shaggy' Rogers (voice) (52 eps)
Patrick Warburton
Sheriff Bronson Stone (voice) (34 eps)
Gary Cole
Mayor Fred Jones Sr. (voice) (23 eps)
Lewis Black
Mr. E (voice) (23 eps)
Vivica A. Fox
Angel Dynamite (voice) (20 eps)
Udo Kier
Professor Pericles (voice) (17 eps)
Kate Higgins
Mayor Janet Nettles (voice) (17 eps)
Frances Conroy
Angie Dinkley (voice) (15 eps)
Tia Carrere
Judy Reeves (voice) (14 eps)
Tim Matheson
Brad Chiles (voice) (13 eps)
Mitch Watson
Ethan (voice) (12 eps)
Kath Soucie
Nan Blake (voice) (11 eps)
Linda Cardellini
Marcie 'Hot Dog Water' Fleach (voice) (9 eps)
John O'Hurley
Skipper Shelton (voice) (8 eps)
Dee Bradley Baker
Kriegstaffebot (Voice) (7 eps)
Maurice LaMarche
Vincent Van Ghoul (voice) (6 eps)
Tony Cervone
Gary (voice) (6 eps)
James Arnold Taylor
George Avocados (voice) (5 eps)
Troy Baker
Blue Falcon (voice) (5 eps)
Fred Tatasciore
The Phantom (voice) (5 eps)
Amy Acker
Nova (voice) (4 eps)
Jeff Bennett
Gary / Dougal McGuiness (voice) (4 eps)
Kimberly Brooks
Cassidy Williams (voice) (4 eps)
Jennifer Hale
Thorn (voice) (4 eps)
Tom Kenny
Funky Phantom (voice) (4 eps)
Carlos Alazraqui
Ernesto (voice) (4 eps)
Richard McGonagle
Ed Machine (voice) (4 eps)
Matt Lanter
Baylor Hotner (voice) (3 eps)
Clancy Brown
Evil Entity (voice) (3 eps)
Christian Lanz
Fernando El Aguirre (voice) (3 eps)
Mindy Sterling
Dean Fenk (voice) (3 eps)
James Patrick Stuart
Dr. Rick Spartan (voice) (3 eps)
Beth Tapper
Brenda (voice) (3 eps)
David Kaye
Dad (voice) (3 eps)
Kevin Michael Richardson
Dan Fluunk (voice) (3 eps)
Kevin Dunn
Dale Dinkley (voice) (3 eps)
Scott Menville
Ricky Owens (voice) (2 eps)
Harlan Ellison
Self (voice) (2 eps)
Michael J. Anderson
Professor Horatio Kharon (voice) (2 eps)
John DiMaggio
Grady Gator (voice) (2 eps)
Billy West
Randy Warsaw (voice) (2 eps)
Jane Wiedlin
Dusk (voice) (2 eps)
Chris Hardwick
Evallo Von Meanskrieg (voice) (2 eps)
Quinton Flynn
Daniel Prezette / Fantzee Pantz / Gus Boggs (voice) (2 eps)
Isabella Acres
Mary-Ann Geerdon / Tiffany / Child #4 / Child #5 (voice) (2 eps)
Mark Hamill
Crybaby Clown (voice) (2 eps)
James Hong
Chen (voice) (2 eps)
Greg Ellis
Charles 'Cachinga' Wheatlesby (voice) (2 eps)
Cree Summer
Paige Kruller (voice) (2 eps)
Eric Bauza
Dr. Zin (voice) (2 eps)
Hynden Walch
Alice May (voice) (2 eps)
Paul Rugg
Dr. Portillo (2 eps)
Jeffrey Combs
H.P. Hatecraft (voice) (2 eps)
Beverly D'Angelo
Mom (voice) (2 eps)
Nolan North
Brad Chiles (voice) (2 eps)
Kari Wahlgren
Judy Reeves (voice) (2 eps)
Julie Bowen
Marion Spartan (voice) (1 eps)
Jim Cummings
Captain Caveman (voice) (1 eps)
Rick D. Wasserman
Lord Infernicus / Boo (voice) (1 eps)
Tricia Helfer
Aphrodite / Amanda Smyth (voice) (1 eps)
James Marsters
Dandy Highwayman (voice) (1 eps)
Martha Quinn
Self (voice) (1 eps)
Clyde Kusatsu
Picnicker (voice) (1 eps)
Christopher Corey Smith
Race Bannon (voice) (1 eps)
Laraine Newman
Granny Snaggletooth (voice) (1 eps)
Charles Shaughnessy
Ned Fussbuster (voice) (1 eps)
Phil LaMarr
Melvin Keisterbaum (voice) (1 eps)
Jason Marsden
Horbert Feist (voice) (1 eps)
John Billingsley
Dr. Henklefust (voice) (1 eps)
Jim Rash
J.R. Kipple (voice) (1 eps)
Roz Ryan
Gorgeous G (voice) (1 eps)
George Takei
Mr. Wang / White Wizard (voice) (1 eps)
Stephanie Sheh
Mai Le (voice) (1 eps)
Gary Anthony Williams
Dr. Cavanaugh (voice) (1 eps)
Powers Boothe
Dead Justice (voice) (1 eps)
Florence Henderson
Ruby Stone (voice) (1 eps)
David Faustino
Bud Coleman (voice) (1 eps)
George Segal
Peter Trickell (voice) (1 eps)
Zach Callison
Arthur Baywosenthal / Child #6 / Child #7 (voice) (1 eps)
Lloyd Sherr
Lord Barry (voice) (1 eps)
Jeffrey Tambor
Gill Littlefoot (voice) (1 eps)
Audrey Wasilewski
Queen Amanda (voice) (1 eps)
Daryl Sabara
Jason (voice) (1 eps)
Jessica Walter
Jason's Mom (voice) (1 eps)
Crispin Freeman
Ben (voice) (1 eps)
Dave Allen
Rick Yantz (voice) (1 eps)
Joe Holt
Hugh Dederdee (voice) (1 eps)
Marion Ross
Grandma Moonbeam (voice) (1 eps)
Phil Idrissi
Gabtraf (voice) (1 eps)
Dwight Schultz
Older Danny Darrow (voice) (1 eps)
Will Shadley
Younger Danny Darrow (voice) (1 eps)
David Juskow
Harry Schnesle-Boysen (voice) (1 eps)
David Kaye
Argus Fentonpoof (voice) (1 eps)
April Winchell
Weena (voice) (1 eps)
Daran Norris
Skipper's Brother (voice) (1 eps)
Rob Paulsen
Winslow Fleach (voice) (1 eps)
David Markus
Young Man / Ben (voice) (1 eps)