Christina Applegate
Samantha Newly (35 eps)
Jennifer Esposito
Andrea Belladonna (35 eps)
Kevin Dunn
Howard (35 eps)
Melissa McCarthy
Dena (35 eps)
Tim Russ
Frank (35 eps)
Barry Watson
Todd (35 eps)
Jean Smart
Regina Newly (35 eps)
Rick Hoffman
Chase Chapman (9 eps)
Stephen Rannazzisi
Seth (6 eps)
Billy Zane
Funk (5 eps)
Kiele Sanchez
Chloe (4 eps)
James Tupper
Owen (4 eps)
Joy Osmanski
Tracy (4 eps)
McKinley Freeman
Tony Dane (4 eps)
Eliza Coupe
Willow (2 eps)
Eddie Cibrian
Kevin (2 eps)
Dana Sorman
Jerri (2 eps)
Adam Devine
Tyler (2 eps)
Nakia Burrise
Kerry Hall (1 eps)
Timothy Olyphant
Winston Funk (1 eps)
Natasha Leggero
Woman Customer (1 eps)
Anthony Anderson
Rafael Grace (1 eps)
Mark Ballas
Mateo Romero (1 eps)
Tony Hale
Andy Adams (1 eps)
Teddy Sears
Brad (1 eps)
Rebecca Wisocky
Lindsey (1 eps)
Brett Rickaby
AA Leader (1 eps)
Beth Littleford
Audrey Rhodes (1 eps)
Ryan Carnes
Brent (1 eps)
Cybill Shepherd
Paula Drake (1 eps)
Mary-Kate Olsen
Natalie (1 eps)
James Patrick Stuart
Bill Jacobs (1 eps)
Andre Ware
Mac Fresh (1 eps)
Jerry O'Connell
Craig (1 eps)
Miranda May
13-Year-Old Dena (1 eps)
William Abadie
Rene (1 eps)
Jelynn Sophia
Angry Woman (1 eps)
Dan Thiel
Dave (1 eps)
Adam Jennings
Barista (1 eps)
Jill Talley
AA Female Leader (1 eps)
Frank Maharajh
Dr. Kegoshian (1 eps)
Jamison Haase
Vic (1 eps)
B.J. Clinkscales
Waiter (1 eps)
Jessica St. Clair
Valerie (1 eps)
Gerald Downey
Paul (1 eps)
Curt Cornelius
Trey (1 eps)
Amanda Young
Paul's Wife (1 eps)
Kara Taitz
Bridesmaid (1 eps)
Ryan Carlberg
Jason (1 eps)
Rand Holdren
Ryan (1 eps)
Sarah Spiegel
Young Woman (1 eps)
Todd Grinnell
Nathan (1 eps)
Johanna Braddy
Teenage Samantha (1 eps)
Jagger Chase
Kid (1 eps)
Anthony R. Jones
Police Sergeant (1 eps)
Kelsey Lee Smith
Young Samantha (1 eps)
Marilyn Sue Perry
Cashier (1 eps)
Arshad Aslam
Barista (1 eps)
Reggie Jordan
Flower Delivery Guy (1 eps)
Timon Kyle Durrett
Russ (1 eps)
Tanya Bond
Girl (1 eps)
Ossie Mair
Driver (1 eps)
Jaclyn Kerhulas
Sign Language Interpreter (1 eps)
Morgan Murphy
Woman Protester (1 eps)
Jim Rash
Artist (1 eps)
Jonathan Schmock
Hipster (1 eps)
Brandon Ford Green
Guy (1 eps)
Ian Duncan
Cameron (1 eps)
Soledad Campos
Woman (1 eps)
Tony Winters
Man (1 eps)
Melody Butiu
Nurse (1 eps)
Brian Catalano
Orderly (1 eps)
Sarah Rafferty
Kayla Kaminski (1 eps)
Gregory Franklin
Announcer (1 eps)
Rachel Cannon
Carol (1 eps)
Phoebe Dorin
Older Woman (1 eps)
Brian D. Phelan
Cute Guy (1 eps)
William Borger
Crying Kid (1 eps)
Roxana Ortega
Allison (1 eps)
Steve Wilson
Foreman (1 eps)
Carla Greene
Waitress (1 eps)
Annette M. Lesure
Waitress (1 eps)
Sayeed Shahidi
Little Boy (1 eps)
Marsh Mokhtari
Mike (1 eps)
Joni Kempner
Cameron (1 eps)
Cooper Thornton
Instructor (1 eps)
David Douglas
Barista (1 eps)
Mary Alyce Kania
Waitress (1 eps)
Barry Finkel
Funeral Director (1 eps)
Laurie Okin
Mother (1 eps)
Stefan Marks
Detective Harp (1 eps)
Ty Barnett
Mugger (1 eps)
Karlton Johnson
Policeman (1 eps)
Tara Ochs
Waitress (1 eps)
Michael Crider
Roth (1 eps)
Ken Rudulph
Reporter (1 eps)
Brent Tarnol
Jason (1 eps)
John Taylor
Tommy Wylder (1 eps)
Greg Cipes
Street Musician (1 eps)
Terryn Westbrook
Female Fan #1 (1 eps)
Kathryn Taylor Smith
Female Fan #2 (1 eps)
Susie Geiser
Woman (1 eps)
Amanda Collier
13-Year-Old Samantha (1 eps)
Dondré Whitfield
Wes Green (1 eps)
Robin Gwynne
Wife (1 eps)
Christine Ebersole
Amy (1 eps)
Florence Henderson
Loretta (1 eps)
Nora Dunn
Cheryl (1 eps)
Hahn Cho
Doctor (1 eps)
Terrance Christopher Jones
Teacher (1 eps)
Abdoulaye NGom
Minister (1 eps)
Jean-Pierre Gillain
Philippe (1 eps)
Denise Gossett
Homeless Woman (1 eps)
Indira G. Wilson
Photographer (1 eps)
Charles C. Stevenson Jr.
Gentleman (1 eps)
Angie Harmon
Gigi (1 eps)
Bree Condon
Mickey (1 eps)
Jackie Johnson
Jackie Johnson (1 eps)
Shulie Cowen
Dolly (1 eps)
Greg Callahan
Fake Dad (1 eps)
David Trice
Baggage Service Rep (1 eps)
Anna Zielinski
Ticket Agent (1 eps)
Andre M. Johnson
Security Guard (1 eps)