Joe Alaskey
Grandpa Lou Pickles (voice) (324 eps)
Elizabeth Daily
Tommy Pickles (voice) (323 eps)
Kath Soucie
Phil DeVille / Lil DeVille (voice) (323 eps)
Melanie Chartoff
Didi Pickles (voice) (323 eps)
Jack Riley
Stu Pickles (voice) (323 eps)
Cheryl Chase
Angelica Pickles (voice) (322 eps)
Cree Summer
Susie Carmichael (voice) (297 eps)
Christine Cavanaugh
Chuckie Finster (voice) (291 eps)
Tara Strong
Dil Pickles (voice) (171 eps)
Dionne Quan
Kimi Finster (voice) (95 eps)
Nancy Cartwright
Chuckie Finster (voice) (32 eps)
Tress MacNeille
Charlotte Pickles (voice) (31 eps)
Tony Jay
Dr. Lipschitz (voice) (7 eps)
Amanda Bynes
Taffy (7 eps)
Candi Milo
Toddler #1 / Operator (voice) (4 eps)
Andrea Martin
Aunt Miriam (voice) (3 eps)
Debbie Reynolds
Lulu Pickles (voice) (2 eps)
Jeremy Sisto
Larry (voice) (2 eps)
David Eccles
Reptar / Dactar / Robot Reptar (voice) (2 eps)
Charlie Adler
Ickis (voice) (2 eps)
Julia Kato
Kira Finster / Woman (voice) (2 eps)
Hope Levy
Candy / Girl (voice) (2 eps)
Dom DeLuise
Director (voice) (1 eps)
Nicole Sullivan
Debbie / Customer (voice) (1 eps)
Drake Bell
Dusty (voice) (1 eps)
Adam West
Captain Blasto (voice) (1 eps)
Andy Houts
Oodles (voice) (1 eps)
June Foray
Blocky / Svetlana (voice) (1 eps)
Mark DeCarlo
Rob Hackett (voice) (1 eps)
Vicki Lewis
Miss Carol (voice) (1 eps)
Stacy Keach
Marvin Finster (voice) (1 eps)
Miriam Margolyes
Shirley Finster (voice) (1 eps)
Gedde Watanabe
Zack (voice) (1 eps)
Rodger Bumpass
Uncle Freddy (voice) (1 eps)
Alyson Hannigan
Cynthia P.I. (voice) (1 eps)
David Bowe
Ticket Taker / Judge (voice) (1 eps)
Adrienne Frantz
Emica (voice) (1 eps)
Laraine Newman
Samantha Shane (voice) (1 eps)
Monica Piper
Miss Guppy (voice) (1 eps)
Keythe Farley
Radio Announcer (voice) (1 eps)
Jennifer Darling
Hat Kid (voice) (1 eps)
Mary Ellen Dunbar
Jungle Gym Kid (voice) (1 eps)
Katie Leigh
New Kid #1 (voice) (1 eps)
Sherry Lynn
Sandbox Kid (voice) (1 eps)
Rosslynn Taylor Jordan
New Kid #2 (voice) (1 eps)
Noelle North
Herbert (voice) (1 eps)
Marianne Muellerleile
Sunny (voice) (1 eps)
Ogie Banks
Token Seller (voice) (1 eps)
Dwight Schultz
Gracko (voice) (1 eps)
Phil Proctor
Howard DeVille (voice) (1 eps)
Garry Marshall
Fred (voice) (1 eps)
S. Scott Bullock
Greeter / Pirate / Salon Guy (voice) (1 eps)
Jesse Corti
Pool Waiter / Pirate (voice) (1 eps)
Leila Kenzle
Tracy (voice) (1 eps)
Kim Mai Guest
Toddler #2 / Girl (voice) (1 eps)
Stuart Stone
Tucker / Falling Waiter (voice) (1 eps)
Scott Wilk
Pirate (voice) (1 eps)