Glenn Quinn
Mark Healy (26 eps)
Roseanne Barr
Roseanne Conner (24 eps)
John Goodman
Dan Conner (24 eps)
Sara Gilbert
Darlene Conner (24 eps)
Michael Fishman
D.J. Conner (24 eps)
Sarah Chalke
Becky Conner-Healy (24 eps)
Laurie Metcalf
Jackie Harris (24 eps)
Johnny Galecki
David Healy (11 eps)
Shelley Winters
Nana Mary (2 eps)
Sandra Bernhard
Nancy (2 eps)
Martin Mull
Leon Carp (2 eps)
Phil Leeds
Grandmama Lily (2 eps)
Stella Butler
Nurse Stella (2 eps)
Arianna Huffington
Estree Longet (1 eps)
Erick Avari
Prince's Assistant (1 eps)
Jim Varney
Prince Carlos (1 eps)
Dana Gould
Chip (1 eps)
Garrett Hazen
Andy Harris (1 eps)
Kent Hazen
Andy Harris (1 eps)
Ronald E. House
Werner (1 eps)
Dina Merrill
Doris (1 eps)
Grinnell Morris
Skip (1 eps)
Cole Roberts
Jerry Garcia Conner (1 eps)
Iqbal Theba
Dr. Bakshi (1 eps)
Hillary Tuck
Kiki (1 eps)
David Mendenhall
Clerk (uncredited) (1 eps)