Roseanne Barr
Roseanne Conner (26 eps)
John Goodman
Dan Conner (26 eps)
Sara Gilbert
Darlene Conner (26 eps)
Michael Fishman
D.J. Conner (26 eps)
Sarah Chalke
Becky Conner-Healy (26 eps)
Laurie Metcalf
Jackie Harris (26 eps)
Johnny Galecki
David Healy (20 eps)
Michael O'Keefe
Fred (12 eps)
Martin Mull
Leon Carp (5 eps)
Joseph Gordon-Levitt
George (2 eps)
Danny Masterson
Jimmy (2 eps)
James Pickens Jr.
Chuck Mitchell (2 eps)
Shelley Winters
Nana Mary (1 eps)
Ellen DeGeneres
Dr. Whitman (1 eps)