Paul Reubens
Pee-wee Herman (13 eps)
Lynne Marie Stewart
Miss Yvonne (13 eps)
Phil Hartman
Captain Carl (13 eps)
Laurence Fishburne
Cowboy Curtis (13 eps)
Gilbert Lewis
The King of Cartoons (13 eps)
S. Epatha Merkerson
Reba (13 eps)
John Paragon
Jambi (13 eps)
Shirley Stoler
Mrs. Steve (13 eps)
Alison Mork
Chairry (voice) / Magic Screen (voice) (13 eps)
Gregory Harrison
Conky 2000 (voice) / Knucklehead (voice) (13 eps)
Natasha Lyonne
Opal (13 eps)
Diane Yang
Cher (13 eps)