Benedict Cumberbatch
Patrick Melrose (5 eps)
Jennifer Jason Leigh
Eleanor Melrose (5 eps)
Hugo Weaving
David Melrose (5 eps)
Sebastian Maltz
Young Patrick Melrose (5 eps)
Jessica Raine
Julia (5 eps)
Prasanna Puwanarajah
Johnny (4 eps)
Pip Torrens
Nicolas Pratt (4 eps)
Indira Varma
Anne Moore (3 eps)
Anna Madeley
Mary Melrose (3 eps)
Holliday Grainger
Bridget Watson-Scott (2 eps)
Gary Beadle
Chilly Willy (2 eps)
Morfydd Clark
Debbie Hickman (2 eps)
John Standing
George Watford (2 eps)
Blythe Danner
Nancy Valance (2 eps)
Celia Imrie
Kettle (2 eps)
Eileen Walsh
Annette (2 eps)
Dainton Anderson
Thomas Melrose (2 eps)
Marcus Smith
Robert Melrose (2 eps)
Guy Paul
Cousin Henry (2 eps)
Jennifer Armour
Border Control Officer (1 eps)
Allison Williams
Marianne Banks (1 eps)
Richard Brake
Mark (1 eps)
David Mills
Hotel Receptionist (1 eps)
Oengus MacNamara
Bellboy (1 eps)
Dempsey Bovell
Drug Dealer 2 (1 eps)
Kevin Layne
Shades (1 eps)
Charley Palmer Rothwell
Drug Dealer 1 (1 eps)
Janine Harouni
Funeral Parlour Receptionist (1 eps)
Michael Levi Harris
Funeral Parlour Waiter (1 eps)
Apple Brook
Elderly Mourner (1 eps)
Kerry Shale
Funeral Director (1 eps)
Cory Peterson
Restaurant Waiter (1 eps)
Andrea Davy
Mrs. Willy (1 eps)
Philip Arditti
Pierre (1 eps)
Matthew Marsh
Ballentine Morgan (1 eps)
Nancy Crane
Nancy Banks (1 eps)
Eben Young
Jerry Banks (1 eps)
James Fleet
Sir Victor Eisen (1 eps)
Chantal Neuwirth
Yvette (1 eps)
Anthony Boyle
Barry (1 eps)
Harriet Walter
Princess Margaret (1 eps)
Hippolyte Girardot
Jacques D'Alantour (1 eps)
Irène Jacob
Jacqueline D'Alantour (1 eps)
Tim McMullan
Sonny Gravesend (1 eps)
Amanda Root
Virginia Watson-Scott (1 eps)
Julian Firth
Tony Fowles (1 eps)
Margo Stilley
Cindy Smith (1 eps)
Richard Dixon
David Windfall (1 eps)
Gabriel Quigley
Nanny (1 eps)
Lila Prideaux
Belinda Gravesend (1 eps)
Anthony Taylor
Harry / Secretary at N.A. (1 eps)
Beatrice Curnew
Angie at N.A. (1 eps)
Georgia Maguire
Amanda Pratt (1 eps)
Jamie Bradley
Peter at N.A. (1 eps)
Richard Attlee
Weather Forecaster (1 eps)
Simon Weir
Angus (1 eps)
Paul Bullion
Security Guard (1 eps)
Martin Ware
Waiter, Cheatley (1 eps)
Jonjo O'Neill
Seamus Dourke (1 eps)
Georgia Goodman
Claudine (1 eps)
Declan Rodgers
Kevin (1 eps)
Dixie Egerickx
Lucy (1 eps)
Elizabeth Berrington
Fleur (1 eps)
Roger Alborough
Funeral Director (1 eps)
Roger Barclay
Doctor Fenelon (1 eps)
Naoko Mori
Doctor Pagazzi (1 eps)
Margaret Clunie
Helen / Waitress (1 eps)
Annabel Mullion
Annabel (1 eps)
Natalie Klamar
Becky (1 eps)
Tom Anderson
Gordon (1 eps)
Bryony Miller
Jill (1 eps)
Cameron Jack
Terry (1 eps)
Neal Barry
Minicab Driver (1 eps)
Eric Meyers
Key Club Member (1 eps)