Tatiana Maslany
Sarah / Cosima / Alison / Helena / Rachel (10 eps)
Jordan Gavaris
Felix 'Fee' Dawkins (10 eps)
Josh Vokey
Scott Smith (10 eps)
Maria Doyle Kennedy
Siobhan 'Mrs. S' Sadler (10 eps)
Ari Millen
Mark / Rudy / Miller / Ira (10 eps)
Kevin Hanchard
Detective Arthur 'Art' Bell (10 eps)
Kristian Bruun
Donald 'Donnie' Hendrix (10 eps)
Skyler Wexler
Kira Manning (10 eps)
Calwyn Shurgold
Hell Wizard (8 eps)
Cynthia Galant
Young Rachel / Charlotte (7 eps)
Andrew Moodie
Simon Frontenac (7 eps)
Stephen McHattie
Percival "P. T." Westmorland (7 eps)
Kyra Harper
Dr. Virginia Coady (6 eps)
Elyse Levesque
Detective Maddy Enger (6 eps)
Eileen Sword
Sister Irina (6 eps)
Jenessa Grant
Mud (5 eps)
Sirena Gulamgaus
Aisha Yasin (5 eps)
Lauren Hammersley
Adele (4 eps)
Stuart Hughes
Cooper (4 eps)
Homa Kameh
Aisha Yasin's Mother (4 eps)
Rosemary Dunsmore
Professor Susan Duncan (3 eps)
Géza Kovács
The Messenger (3 eps)
Victor Gomez
Salvador (3 eps)
Vas Saranga
Amar (3 eps)
Andrew Musselman
The Creature / Janis (3 eps)
Elie Gemael
Hashem Al-Khatib (3 eps)
Ron Lea
Lieutenant Gavin Hardcastle (2 eps)
Zoé De Grand Maison
Gracie Johanssen (2 eps)
James Frain
Ferdinand Chevalier (2 eps)
Nicholas Rose
Colin (2 eps)
Ryan Blakely
Reverend Mike (2 eps)
Scott Wentworth
Dr. Ian Van Lier (2 eps)
Calvin Desautels
Neo Agent #1 (2 eps)
Deborah Grover
Yolanda (2 eps)
Humberly González
Ana (2 eps)
Mike Shara
Guard #2 (2 eps)
Ted Dykstra
Doctor (2 eps)
Matt Frewer
Dr. Aldous Leekie (1 eps)
Daniel Kash
Tomas (1 eps)
Natalie Lisinska
Aynsley Norris (1 eps)
Eric Johnson
Chad Norris (1 eps)
Diana Salvatore
Bobby (1 eps)
Millie Davis
Gemma Hendrix (1 eps)
Earl McLean Jr.
Teddy (1 eps)
Ava Arrindell
Maya Bell (1 eps)
Bobby Brown
Neo Agent #3 (1 eps)
Glenda Braganza
Dr. Slaight (1 eps)
Simu Liu
Mr. Mitchell (1 eps)
Karen Ivany
Vice Principal (1 eps)
Bas Reitsma
Neo Agent (1 eps)
Tim Beresford
Neo Agent (1 eps)
Paula Barrett
Nurse Wennie (1 eps)
Dalton Derek
Security Guard (1 eps)
Sheila McCarthy
Connie Hendrix (voice) (1 eps)
Jayne Eastwood
Nona Walker (1 eps)
Illarion Michaels
Jake (1 eps)
Lily Gail Reid
Esmae (1 eps)
Marco Timpano
Forensics #1 (1 eps)
Christina Ferrel
Eilleen (1 eps)
Sarah Orenstein
Dr. Elizabeth Perkins (1 eps)
Varun Saranga
Neal (1 eps)
Pip Dwyer
Cedar Ridge Nurse (1 eps)
Doug Murray
Dr. Nimitz (1 eps)
Jonathan Goldapple
Waiter (1 eps)
Joel Chico
Wei (1 eps)
Daniel Stolfi
Village Guard (1 eps)
Cara Ricketts
Brie (1 eps)
Lukas Engel
Boy (1 eps)
Tom Cullen
Leonard "Len" Sipp (1 eps)
Andy Marshall
Technician (1 eps)
Steven Gallagher
Male Physician (1 eps)
Kent Staines
Ezra Lue (1 eps)
Leon Aureus
Back Alley Surgeon (1 eps)
Suresh John
Krishna (1 eps)
Leslie McBay
Bev (1 eps)
Craig Henry
Steve (1 eps)
Habree Larratt
Young Helena (1 eps)
Cynthia Ashperger
Sister Olga (1 eps)
Aviva Armour-Ostroff
Coady's Technician (1 eps)
Nneka Elliott
News Reporter (1 eps)
Christopher Morris
Kiosk Guard (1 eps)
Sally Cahill
Irish Friend (1 eps)
Lisa MacIsaac
A Capella Singer (1 eps)
Mark Sparks
Guard #3 (1 eps)
Bailey Corneal
Clone B (1 eps)
Heidi Malley
Clone C (1 eps)
Courtenay Taylor
Michael (1 eps)