Chad Michael Murray
Lucas Scott (22 eps)
James Lafferty
Nathan Scott (22 eps)
Bethany Joy Lenz
Haley James Scott (22 eps)
Sophia Bush
Brooke Davis (22 eps)
Hilarie Burton
Peyton Sawyer (22 eps)
Lee Norris
Marvin 'Mouth' McFadden (22 eps)
Barry Corbin
Whitey Durham (22 eps)
Moira Kelly
Karen Roe (22 eps)
Paul Johansson
Dan Scott (22 eps)
Barbara Alyn Woods
Deb Scott (22 eps)
Danneel Ackles
Rachel Gatina (18 eps)
Bevin Prince
Bevin (16 eps)
Sheryl Lee
Ellie Harp (8 eps)
Vaughn Wilson
Fergie (7 eps)
Tyler Hilton
Chris Keller (6 eps)
Antwon Tanner
Antwon 'Skills' Taylor (6 eps)
Kevin Kilner
Larry Sawyer (6 eps)
Cullen Moss
Junk (6 eps)
Kelsey Asbille
Gigi (5 eps)
Brett Claywell
Tim Smith (5 eps)
Bryan Greenberg
Jake Jagielski (3 eps)
Michael Trucco
Cooper Lee (3 eps)
Johanna Jowett
Store Manager (3 eps)
Pete Wentz
Pete Wentz (3 eps)
John Cates
Rusty (3 eps)
Patrick Stogner
Young Keith (3 eps)
Texas Battle
Tony Battle (2 eps)
Colin Fickes
Jimmy Edwards (2 eps)
Marcus Coloma
Marcus Johnson (2 eps)
Chip Lane
Firefighter (2 eps)
Mark Joy
Mayor Mullins (2 eps)
Michael Harding
Chief (2 eps)
Joe Trohman
Joe Trohman (2 eps)
David Bridgewater
Reeves (2 eps)
Patrick Stump
Patrick Stump (2 eps)
Renee Vincent
Mrs. Edwards (2 eps)
Marcus Lyle Brown
Priest (2 eps)
Andy Hurley
Andy Hurley (2 eps)
Austin James
Terry (2 eps)
Chelsea Golden
Chelsea (2 eps)
Zachary Dylan Smith
Young Dan (2 eps)
Joshua Snyder
Damien West (1 eps)
Peyton List
Solaris (1 eps)
Brendan Kirsch
Brendan (1 eps)
Jimmy Hager
Priest (1 eps)
Tilky Jones
Lifeguard (1 eps)
Andrew Springer
Lifeguard #2 (1 eps)
Heather Philipsen
Amy (1 eps)
Juliet Cesario
Bustier Woman (1 eps)
Stacey J. Aswad
Woman (1 eps)
Billy Dickson Jr.
Punk (1 eps)
Taylor Webb
Sue (1 eps)
Anna Stromberg
Catty Girl #2 (1 eps)
Ashley Gorrell
Catty Girl #3 (1 eps)
Suzanne Quast
Stripper (1 eps)
Peyton Lee
Hans (1 eps)
Arielle Grace Quattro
Kiki (1 eps)
Kenzie Dalton
Cheerleader (1 eps)
Samuel Elliott Whisnant
Guy (1 eps)
David Temple
DJ (1 eps)
Julianna Guill
Ashley (1 eps)
Danny Woodburn
Marty (1 eps)
Chris Haywood
Shop Owner (1 eps)
Dave Cohen
Sportscaster (1 eps)
Jennifer Keddy
Peyngel (1 eps)
Tim Parati
Dexter (1 eps)
Kelvin Amburgey
Emanuelle (1 eps)
John Keenan
Police Officer (1 eps)
Belinda Keller
Female Officer (1 eps)
April Turner
Woman (1 eps)
L.J. Woodard
Reporter (1 eps)
Brett Pryor
Advisor (1 eps)
Dominic L. Santana
Henchman (1 eps)
Pete Burris
Riverboat Cop (1 eps)
Mekia Cox
Faith Banks (1 eps)
Sarah Sullivan
Tara (1 eps)
Cooper Musgrove
Tommy (1 eps)
Chris Drake
Joe (1 eps)
Brandon Xavier
Chuck (1 eps)
Phillip DeVona
Band Manager (1 eps)
Donna Cooper
Guidance Counselor (1 eps)
David Reinwald
Scout (1 eps)
Don A. King
Police Detective (1 eps)
Brian George
Daoud (1 eps)
Gregory Alan Williams
Chuck (1 eps)
Allison Scagliotti
Abby Brown (1 eps)
Sheila Cutchlow
Susan (1 eps)
Natalie Khoury
Juliet (1 eps)
Robert C. Treveiler
Preacher (1 eps)
Brandon Wade
Brandon (1 eps)
Keith Pratt
Billy (1 eps)
Michelle Featherstone
Michelle Featherstone (1 eps)
Sean Guerrero
Bartender (1 eps)
Amber Wallace
Glenda (1 eps)
Sarah Edwards
Theresa (1 eps)
Jody Whitehurst
Customer (1 eps)
Frances Anne Civitano
Nervous Girl (1 eps)
Jessica Looney
Perky Girl (1 eps)
Mark Andrew Jones
Geeky Guy (1 eps)
Johanna Collins
Normal Girl (1 eps)
Danielle Motley
Clown Girl (1 eps)
Jocelyn Rose
Teacher (1 eps)
Jennifer Lucaciu
Cheerleader (1 eps)
Victoria Jones
Cheerleader (1 eps)
Daniel Smith
Daniel (1 eps)
Mary Carol Erny
Metermaid (1 eps)
Tamara Morgan
Cheerleader (1 eps)
Tom Bosley
Mel McFadden (1 eps)
Jimmy Moore
Engineer (1 eps)
Justin Colvin
Policeman (1 eps)
Narayan Sanders
Player (1 eps)
Jackson Pearce
Young Keith (1 eps)
Charlie Garland
Young Dan (1 eps)
Patricia Wells
Bank Manager (1 eps)
Destiny Lamb
Leah (1 eps)
Khari King
Cam (1 eps)
Sam Robinson
Travis (1 eps)
Jeremy DeCarlos
Dallas (1 eps)
Tammy Fontaine
Stagehand (1 eps)
Jonathan Furr
Dunlap Brother #1 (1 eps)
Sean Johnson
Dunlap Brother #2 (1 eps)
Melissa Seitz
Cute Girl (1 eps)
John R. Brennan
Friend #1 (1 eps)
Nina Jones
Mrs. Farrell (1 eps)
Sharon Graci
Sheila (1 eps)
Teresa Smith
Concerned Parent #1 (1 eps)
Jeff Howard
Officer #3 (1 eps)
Bobby Kennedy
SWAT #1 (1 eps)
Byron Thigpen
SWAT #2 (1 eps)
Chris Mink
Young Nathan (1 eps)
Mark Wilson
Oak Lake Coach (1 eps)
Gabe Wood
Ref (1 eps)
Jeff Loman
Radio Announcer (voice) (1 eps)