Chad Michael Murray
Lucas Scott (22 eps)
James Lafferty
Nathan Scott (22 eps)
Bethany Joy Lenz
Haley James Scott (22 eps)
Sophia Bush
Brooke Davis (22 eps)
Hilarie Burton
Peyton Sawyer (22 eps)
Barry Corbin
Whitey Durham (22 eps)
Craig Sheffer
Keith Scott (22 eps)
Moira Kelly
Karen Roe (22 eps)
Paul Johansson
Dan Scott (22 eps)
Brett Claywell
Tim Smith (20 eps)
Barbara Alyn Woods
Deb Scott (19 eps)
Bryan Greenberg
Jake Jagielski (13 eps)
Lee Norris
Marvin 'Mouth' McFadden (12 eps)
Vaughn Wilson
Fergie (7 eps)
Cullen Moss
Junk (7 eps)
Antwon Tanner
Antwon 'Skills' Taylor (6 eps)
Emmanuelle Vaugier
Nicki (6 eps)
Bevin Prince
Bevin (6 eps)
Thomas Ian Griffith
Larry Sawyer (5 eps)
Dorothy Recasner Brown
Dr. Hale (4 eps)
Sarah Edwards
Theresa (4 eps)
Amy Parrish
Shari Smith (3 eps)
Ann Cusack
Nora Thorpe (2 eps)
Joan Severance
Cynthia Price (2 eps)
Jason Davis
Mr. Kelly (2 eps)
Melissa Claire Egan
Lori (2 eps)
Drew Seeley
Johnny 'Vegas' Norris (2 eps)
Andrew Masset
Dr. Ryan (2 eps)
Rick Forrester
Matt Perry (2 eps)
Dean James
Bartender (2 eps)
Leigh Jones
Pretty Girl (2 eps)
Colin Fickes
Jimmy Edwards (2 eps)
Melissa Ponzio
Alice (2 eps)
Shawn Shepard
Principal Turner (2 eps)
Greg Thompson
Dr. Adams (2 eps)
Traci Dinwiddie
Waitress (1 eps)
Corri English
Claire Young (1 eps)
Sam Horrigan
Thing (1 eps)
Austin Carty
Young Dan (1 eps)
Sean Faris
Abercrombie (1 eps)
Gavin DeGraw
Gavin DeGraw (1 eps)
Dave Power
Thing #3 (1 eps)
Mike Erwin
Gabe (1 eps)
Blake Bashoff
Gary Matheson (1 eps)
Paula Trickey
Carrie (1 eps)
Tess Harper
May Scott (1 eps)
Samantha Shelton
Reagan (1 eps)
B.J. Britt
Ref (1 eps)
Rhoda Griffis
Rachel (1 eps)
Corey A. Jackson
Brandon (1 eps)
Nancy Moreno
Young Karen (1 eps)
Terry Horton
PA Announcer (voice) (1 eps)
Jon Stafford
Max (1 eps)
Tracy Williams
Bruce (1 eps)
Dan Becker
Thing #1 (1 eps)
Beth W. Crookham
Caterer (1 eps)
Hatcher Flaschen
R.A. (1 eps)
Tilky Jones
Max (1 eps)
Terry Loughlin
Dr. Milford (1 eps)
Marcus Bryant
Springer (1 eps)
Brian Lafontaine
Bellman (1 eps)
Erin Cline
Cute Waitress (1 eps)
Jason Saucier
Customer (1 eps)
Michael Harding
Cop (1 eps)
Jennifer Massey
Lorraine (1 eps)
Sheryl Crow
Sheryl Crow (1 eps)
Brecka Coleman
Reese (1 eps)
John Driscoll
Club Boy (1 eps)
Melissa Bragg Lumsden
Girl #2 (1 eps)
Zachary Hermann
Player #2 (1 eps)
Kwame Heyward
Player #1 (1 eps)
Richard Bryant
Stoner #1 (1 eps)
Dan Cox
Customer (1 eps)
Adam Heffernan
College Guy (1 eps)
Stephen Delaney
Policeman (1 eps)
Henry Garrett Droege
Messenger (1 eps)
Richard Fullerton
Security Guard (1 eps)
R. Keith Harris
Doctor (1 eps)
Brendan Kirsch
Brendan (1 eps)
Marcela Morgan
Nurse (1 eps)
John Keenan
Officer Wayman (1 eps)
Cedric Pendleton
Jeff Nelson (1 eps)
Marc Tschudi
Kid (1 eps)
Robert C. Treveiler
Entrepreneur (1 eps)
Jeff Wicker
MC (1 eps)
Mitchell Laurance
Peter (1 eps)
Darryl van Leer
Chuck T. (1 eps)
Stephanie Wallace
Casey (1 eps)
Mark Ellis
Ref (1 eps)
Andrea Bowen
Stella (uncredited) (1 eps)
Brandi Ryans
Singing Girl (1 eps)
Gerald McRaney
Royal Scott (1 eps)
Gil Johnson
Road Worker (1 eps)
Angie Fox
Amy Quinn (1 eps)
Christopher Smith
Guitarist (1 eps)
Sarah Lucas
Cheerleader #1 (1 eps)
Maya Tai Dorsey
Girl (1 eps)
Johanna Jowett
Girl #1 (1 eps)
Caitlin Van Hecke
Girl #3 (1 eps)
Lou Criscuolo
Driver (1 eps)
Julianna Guill
Money Girl (1 eps)
J.R. Rodriguez
Buyer (1 eps)
Mike Pniewski
Mr. Carlson (1 eps)
Bobby Tyson
Cop (1 eps)
Drake Johnson
Party Kid (1 eps)
Jennifer Owens
Cop #2 (1 eps)
Ryan Kowalske
Stoner #2 (1 eps)
James Rhodes
Thadeus (1 eps)
Lee Freeman
Booster #2 (1 eps)
Christopher Duncan
Kid #2 (1 eps)
Edith Snow
Nurse Molly (1 eps)
Sam Robison
Trainer (1 eps)