Edie Falco
Jackie Peyton (80 eps)
Paul Schulze
Eddie Walzer (80 eps)
Peter Facinelli
Dr. Fitch Cooper (80 eps)
Merritt Wever
Zoey Barkow (80 eps)
Stephen Wallem
Thor Lundgren (80 eps)
Dominic Fumusa
Kevin Peyton (80 eps)
Ruby Jerins
Grace Peyton (80 eps)
Anna Deavere Smith
Gloria Akalitus (80 eps)
Mackenzie Aladjem
Fiona Peyton (80 eps)
Lenny Jacobson
Lenny (68 eps)
Eve Best
Dr. Eleanor O'Hara (46 eps)
Arjun Gupta
Sam (34 eps)
Betty Gilpin
Dr. Carrie Roman (34 eps)
Haaz Sleiman
Mohammed 'Mo-Mo' De La Cruz (12 eps)
Jake Cannavale
Charlie Cruz (10 eps)
Michael Buscemi
God (8 eps)
Greta Lee
Nurse (3 eps)
Daniel London
Mr. Batali (2 eps)
Quincy Dunn-Baker
Policeman Brother (1 eps)
Christopher Abbott
Andy Singer (1 eps)
Purva Bedi
Tazim (1 eps)
Leslie Silva
Nurse Jackie (1 eps)
Adriane Lenox
NURSE JACKIE (1 eps)
Robbie Tann
Steve (1 eps)
Deirdre O'Connell
Helen (1 eps)
Laura Silverman
Laura (1 eps)
Patrick Breen
Martin Vobernick (1 eps)
Kalani Queypo
Joseph Delaronde (1 eps)
Dave Shalansky
Rick (1 eps)
Rhiannon Giddens
Square Dance Caller (1 eps)
Darby Lynn Totten
Woman (1 eps)
Pallavi Sastry
Allison (1 eps)
Skylar Gaertner
Jake (1 eps)
Sondra James
Mrs. Feinberg (1 eps)
Theo Stockman
Kyle Finch (1 eps)
Manu Narayan
Paramedic (1 eps)
Xosha Roquemore
City Island Clerk (1 eps)
Cristin Milioti
Monica (1 eps)