Pedro Pascal
Javier Peña (30 eps)
Alberto Ammann
Pacho Herrera (21 eps)
Wagner Moura
Pablo Escobar (20 eps)
Boyd Holbrook
Steve Murphy (20 eps)
Joanna Christie
Connie Murphy (20 eps)
Paulina Gaitán
Tata Escobar (20 eps)
Paulina García
Hermilda Gaviria (15 eps)
Matias Varela
Jorge Salcedo (10 eps)
Damián Alcázar
Gilberto Rodríguez Orejuela (10 eps)
Francisco Denis
Miguel Rodríguez Orejuela (10 eps)
Maurice Compte
Horacio Carrillo (10 eps)
Stephanie Sigman
Valeria Velez (10 eps)
Pêpê Rapazote
Chepe Santacruz Londoño (10 eps)
Arturo Castro
David Rodriguez (10 eps)
Michael Stahl-David
Chris Feistl (10 eps)
Matt Whelan
Daniel Van Ness (10 eps)
Diego Cataño
La Quica (10 eps)
Jorge A. Jimenez
Poison (10 eps)
Juan Pablo Raba
Gustavo Gaviria (10 eps)
Raúl Méndez
Cesar Gaviria (10 eps)
Bruno Bichir
Fernando Duque (10 eps)
Luis Guzmán
José Rodríguez Gacha (10 eps)
Martina García
Maritza (10 eps)
Brett Cullen
Arthur Crosby (10 eps)
Andrea Londo
Maria Salazar (10 eps)
Manolo Cardona
Eduardo Sandoval (10 eps)
Eric Lange
Bill Stechner (9 eps)
Sebastián Vega
Hugo Martinez Jr. (6 eps)
Javier Cámara
Guillermo Pallomari (6 eps)
Ana de la Reguera
Elisa Alvaro (5 eps)
Raymond Ablack
Stoddard (5 eps)
José María Yázpik
Amado Carrillo Fuentes (4 eps)
Lux Pascal
Elias (2 eps)
Pablo Escobar
Self (archive footage) (2 eps)
André Mattos
Jorge Luis Ochoa (1 eps)
Roberto Urbina
Fabio Ochoa (1 eps)
Juan Riedinger
Carlos Lehder (1 eps)
Richard T. Jones
Agent DEA (1 eps)
A.J. Buckley
Kevin Brady (1 eps)
Luis Gnecco
La Cucaracha (1 eps)
Jon Ecker
The Lion (1 eps)
Ariel Sierra
Sure Shot (1 eps)
Julián Díaz
El Negro (1 eps)
Carolina Gaitán
Marta Ochoa (1 eps)
Jorge Monterrosa
Trujillo (1 eps)
Alfredo Castro
Abel Escobar (1 eps)
Konstantin Melikhov
Edward Jacoby (1 eps)
Victoria Gaitán
Ticket Agent (1 eps)
Ronald Reagan
Self (archive footage) (1 eps)
Nancy Reagan
Self (archive footage) (1 eps)
Adria Arjona
Helena (1 eps)
Laura Perico
Marina Ochoa (1 eps)
Cristina Umaña
Judy Moncada (1 eps)