Yannick Bisson
Detective William Murdoch (13 eps)
Helene Joy
Dr. Julia Ogden (13 eps)
Jonny Harris
Constable George Crabtree (13 eps)
Georgina Reilly
Dr. Emily Grace (13 eps)
Lachlan Murdoch
Constable Henry Higgins (13 eps)
Jonathan Watton
Dr. Darcy Garland (13 eps)
Thomas Craig
Inspector Thomas Charles Brackenreid (13 eps)
Charles Vandervaart
John Brackenreid (2 eps)
Andrew Gower
Sherlock Holmes / David Kingsley (1 eps)
Amber Goldfarb
Hannah Rice (1 eps)
Patrick Garrow
Helmut Lindermann (1 eps)
Geraint Wyn Davies
Arthur Conan Doyle (1 eps)
Ruth Goodwin
Amelia Richards (uncredited) (1 eps)