Billy Gardell
Mike Biggs (23 eps)
Melissa McCarthy
Molly Flynn (23 eps)
Reno Wilson
Carl McMillan (23 eps)
Swoosie Kurtz
Joyce Flynn (23 eps)
Katy Mixon
Victoria Flynn (23 eps)
Louis Mustillo
Vincent Moranto (23 eps)
Rondi Reed
Margaret 'Peggy' Biggs (23 eps)
Nyambi Nyambi
Samuel (23 eps)
Holly Robinson Peete
Christina (8 eps)
Laura Coover
Rebecca (3 eps)
Cheryl Hawker
Lynette (3 eps)
Francis Guinan
Jack Biggs (3 eps)
Reginald VelJohnson
Brother Heywood (3 eps)
Marianne Muellerleile
Connie (2 eps)
Cole Jensen
Willie (1 eps)
Coby Ryan McLaughlin
Gianni (1 eps)
William Sanderson
Dennis (1 eps)
Sally Champlin
Diane (1 eps)
John Charles Meyer
Dylan (1 eps)
Alexander Arzu
Harry Potter (1 eps)
Elsie Fisher
Fairy Princess (1 eps)
Logan Kishi
Diktrom (1 eps)
Gibson Bobby Sjobeck
Batman (1 eps)
Brian Stepanek
Voltaire (1 eps)
Rachel Brett
Babysitter (1 eps)
Cathy Fielding
Jane Goodall (1 eps)
Terry Finn
Eleanor Roosevelt (1 eps)
Alan Gray
Galileo (1 eps)
Mark Roman
Thomas Jefferson (1 eps)
Steve Hytner
Principal Gilmartin (1 eps)
Brendan Patrick Connor
George (1 eps)
Kevin Brief
Al (1 eps)
Carol Lyn Black
Birdie (1 eps)
Isabella Crovetti
Cindy (1 eps)
Sonya Eddy
Kay (1 eps)
Ryan Malgarini
Matt (1 eps)
Cole Sand
Satchel (1 eps)
Haley Tju
Missy (1 eps)
Nate Mooney
Oswald (1 eps)
Robert Pescovitz
Man (1 eps)
Diarra Kilpatrick
Amira (1 eps)
Howard Hesseman
Otis (1 eps)
Alexandra Hoover
Woman (1 eps)
Keong Sim
Dr. Shufeldt (1 eps)
Mike Jerome Putnam
James (1 eps)
Josh Dean
Father Justin (1 eps)
Betsy Zajko
Crystal (1 eps)
Cerina Vincent
Desri (1 eps)
Larisa Oleynik
Allison (1 eps)
Davenia McFadden
Julie (1 eps)
Savvy Crawford
Little Victoria (1 eps)
Katelyn Coon
Young Molly (1 eps)
Jennifer Baxter
Annette (1 eps)
T.J. Hoban
Anton (1 eps)
Lamont Thompson
Andre (1 eps)
June Squibb
Francine (1 eps)
Dave Allen
Tom (1 eps)