Sarah Parish
Lucrezia de' Medici (12 eps)
Daniel Sharman
Lorenzo de' Medici (8 eps)
Synnøve Karlsen
Clarice Orsini (8 eps)
Alessandra Mastronardi
Lucrezia Donati (8 eps)
Sebastian de Souza
Sandro Botticelli (8 eps)
Francesco Montanari
Girolamo Savonarola (8 eps)
Johnny Harris
Bruno Bernardi (8 eps)
Gualtiero Burzi
Fra Quintino (8 eps)
David Brandon
Petrucci (7 eps)
Louis Partridge
Piero de' Medici (4 eps)
William Franklyn-Miller
Giovanni de' Medici (4 eps)
Jack Roth
Girolamo Riario (1 eps)
Nico Delpiano
Young Giovanni (1 eps)