Richard Madden
Cosimo de' Medici (8 eps)
Stuart Martin
Lorenzo de' Medici (8 eps)
Annabel Scholey
Contessina de' Medici (8 eps)
Guido Caprino
Marco Bello (8 eps)
Alessandro Sperduti
Piero de' Medici (8 eps)
Ken Bones
Ugo Bencini (8 eps)
Lex Shrapnel
Rinaldo Albizzi (8 eps)
Daniel Caltagirone
Andrea de' Pazzi (8 eps)
Valentina Bellè
Lucrezia Tornabuoni (8 eps)
Alessandro Preziosi
Filippo Brunelleschi (8 eps)
Eugenio Franceschini
Ormanno degli Albizzi (8 eps)
Sarah Felberbaum
Maddalena (8 eps)
Miriam Leone
Bianca (8 eps)
Michael Schermi
Ricciardo (8 eps)
Tatjana Nardone
Emilia (8 eps)
Valentina Cervi
Alessandra Ricco (8 eps)
Brian Cox
Bernardo Guadagni (8 eps)
Dustin Hoffman
Giovanni de' Medici (8 eps)
Edward Dring
Choirboy (2 eps)
Antonio De Matteo
Claudio (Guard) (1 eps)