Diamond White
Lunella Lafayette/Moon Girl (voice) (16 eps)
Fred Tatasciore
Devil Dinosaur (voice) (16 eps)
Alfre Woodard
Mimi Lafayette (voice) (16 eps)
Gary Anthony Williams
Pops Lafayette (voice) (16 eps)
Sasheer Zamata
Adria Lafayette (voice) (16 eps)
Jermaine Fowler
James Lafayette Jr. (voice) (16 eps)
Libe Barer
Casey Calderon (voice) (16 eps)
Laurence Fishburne
The Beyonder (voice) (10 eps)
Michael Cimino
Eduardo (voice) (5 eps)
Craig Robinson
Principal Nelson (voice) (2 eps)
Alison Brie
Aftershock (voice) (1 eps)
Utkarsh Ambudkar
Anand (voice) (1 eps)
Josh Keaton
Angelo (voice) (1 eps)
Asia Kate Dillon
LOS-307 (voice) (1 eps)
Jennifer Hudson
Mane (voice) (1 eps)
Daveed Diggs
Rat King (voice) (1 eps)
Mae Jemison
Skipster (voice) (1 eps)