Clark Gregg
Phil Coulson (22 eps)
Chloe Bennet
Daisy 'Skye' Johnson / Quake (22 eps)
Elizabeth Henstridge
Jemma Simmons (22 eps)
Ming-Na Wen
Melinda May (22 eps)
Henry Simmons
Alphonso 'Mack' Mackenzie (22 eps)
Gabriel Luna
Robbie Reyes / Ghost Rider (22 eps)
Iain De Caestecker
Leo Fitz (22 eps)
John Hannah
Holden Radcliffe (22 eps)
Mallory Jansen
Aida (18 eps)
Patrick Cavanaugh
Agent Burrows (12 eps)
Maximilian Osinski
Davis (11 eps)
Zach McGowan
Anton Ivanov (7 eps)
Lilli Birdsell
Lucy Bauer (5 eps)
Parminder Nagra
Senator Ellen Nadeer (5 eps)
José Zúñiga
Eli Morrow (5 eps)
Briana Venskus
Piper (5 eps)
Lorenzo James Henrie
Gabriel Reyes (3 eps)
John Pyper-Ferguson
Tucker Shockley (3 eps)
Derek Phillips
Agent O'Brien (3 eps)
Manish Dayal
Vijay Nadeer (3 eps)
Ward Roberts
Hugo (3 eps)
Alexander Wraith
Agent Anderson (2 eps)
Taj Speights
Burnell (2 eps)
Adam Kulbersh
Kenneth Turgeon (1 eps)
Patton Oswalt
Billy Koenig / Sam Koenig / Thurston Koenig (1 eps)
Artemis Pebdani
L.T. Koenig (1 eps)
Jade Harlow
Julia Price (1 eps)
Ava Acres
Katya Belyakov (1 eps)
Kavita Patil
Mrs. Lee (1 eps)
Nico David
Boy (1 eps)
Axle Whitehead
JT James / Hellfire (1 eps)
J. Michael Evans
Airman Richardson (1 eps)
Tom Virtue
Motel Clerk (1 eps)
Jonathan Stanley
Attendant (1 eps)