Clark Gregg
Phil Coulson (22 eps)
Chloe Bennet
Daisy 'Skye' Johnson / Quake (22 eps)
Elizabeth Henstridge
Jemma Simmons (22 eps)
Ming-Na Wen
Melinda May (22 eps)
Brett Dalton
Grant Ward / Hive (22 eps)
Henry Simmons
Alphonso 'Mack' Mackenzie (22 eps)
Iain De Caestecker
Leo Fitz (22 eps)
Nick Blood
Lance Hunter (22 eps)
Adrianne Palicki
Bobbi Morse (22 eps)
Luke Mitchell
Lincoln Campbell (22 eps)
Mark Dacascos
Giyera (11 eps)
Powers Boothe
Gideon Malick (10 eps)
Constance Zimmer
Rosalind Price (7 eps)
Blair Underwood
Andrew Garner (7 eps)
Matthew Willig
Lash (6 eps)
Juan Pablo Raba
Joey Gutierrez (6 eps)
Axle Whitehead
JT James / Hellfire (6 eps)
Daz Crawford
Kebo (4 eps)
Alexander Wraith
Agent Anderson (4 eps)
Spencer Treat Clark
Werner von Strucker (4 eps)
William Sadler
President Ellis (3 eps)
Gabriel Salvador
Lucio (3 eps)
Katie Hilliard
Tina (2 eps)
Dillon Casey
Will Daniels (2 eps)
Ravil Isyanov
Anton Petrov (2 eps)
Peter MacNicol
Professor Elliott Randolph (1 eps)
Ido Mor
Yusef Hadad (1 eps)
Rob Silverman
Kevin (1 eps)
Briana Venskus
Piper (1 eps)
Amanda Rea
Aida (voice) (1 eps)
Nick Eversman
Shane Larson (1 eps)
Camille De Pazzis
Anon (1 eps)
Brian Patrick Wade
Carl Creel (1 eps)
Alexandra Bokyun Chun
Xiao Chen (1 eps)
Melissa Bickerton
Ellen King (1 eps)
Tohoru Masamune
Haruto Yakimura (1 eps)
Raquel Gardner
Carla Talbot (1 eps)
Jude Lanston
Soldier (1 eps)
Sufian Kassam
Driver (1 eps)
Daniel Messier
Heavy (1 eps)
Kacey Montoya
Reporter (1 eps)
Mike C. Nelson
Witness (1 eps)
Bayo Akinfemi
Nathi Zuma (1 eps)
Hector Hugo
Jerome Deschamps (1 eps)
Marco Martinez
Officer Stuart (1 eps)
Anthony Corrales
S.H.I.E.L.D. Agent (1 eps)
Mike Miller
S.H.I.E.L.D. Medic (1 eps)
Nick Brett
Hydra Arsonist (1 eps)