Maile Flanagan
Piggley Winks (voice) (52 eps)
Russi Taylor
Ferny the Bull / Mrs. Winks (voice) (52 eps)
Tara Strong
Dannan the Duck / Molly Winks (voice) (52 eps)
Mel Brooks
Wiley (voice) (52 eps)
Peadar Lamb
Grandpa Piggley (voice) (52 eps)
Nika Futterman
Sean / Seamus (voice) (52 eps)
Melissa Disney
Meg (voice) (52 eps)
Charlie Adler
Patrick Winks / Mr. Hornsby (voice) (52 eps)
Fernando Escandon
Don Toro (voice) (52 eps)
Pamela Adlon
Hector (voice) (52 eps)
Katie Leigh
Additional Voices (voice) (8 eps)
Candi Milo
Gosford (voice) (7 eps)
Susan Silo
Miss Nanny (voice) (6 eps)
Kath Soucie
Millie (voice) (6 eps)
Brendan Gleeson
Ferny Toro (voice) (2 eps)
David Kelly
Captain Cumara (voice) (1 eps)