Pablo Schreiber
Master Chief, Spartan-117 / John-117 (8 eps)
Natascha McElhone
Dr. Catherine Halsey (8 eps)
Joseph Morgan
James Ackerson (8 eps)
Shabana Azmi
Margaret Parangosky (8 eps)
Christina Bennington
Cortana (8 eps)
Natasha Culzac
Riz-028 (8 eps)
Olive Gray
Dr. Miranda Keyes (8 eps)
Yerin Ha
Kwan Ha (8 eps)
Bentley Kalu
Vannak-134 (8 eps)
Charlie Murphy
Makee (8 eps)
Fiona O'Shaughnessy
Laera (8 eps)
Cristina Rodlo
Corporal Talia Perez (8 eps)
Danny Sapani
Jacob Keyes (8 eps)
Jen Taylor
Cortana (voice) (8 eps)
Viktor Åkerblom
Arbiter Var 'Gatanai (8 eps)
Tylan Bailey
Kessler (8 eps)
Bokeem Woodbine
Soren-066 (8 eps)