Ellen Pompeo
Meredith Grey (24 eps)
Chandra Wilson
Miranda Bailey (24 eps)
Sandra Oh
Cristina Yang (24 eps)
James Pickens Jr.
Richard Webber (24 eps)
Kevin McKidd
Owen Hunt (24 eps)
Katherine Heigl
Izzie Stevens (24 eps)
Kim Raver
Teddy Altman (24 eps)
Justin Chambers
Alex Karev (24 eps)
Sara Ramirez
Callie Torres (24 eps)
Jessica Capshaw
Arizona Robbins (24 eps)
Patrick Dempsey
Derek Shepherd (24 eps)
Eric Dane
Mark Sloan (24 eps)
Chyler Leigh
Lexie Grey (24 eps)
Nora Zehetner
Reed Adamson (10 eps)
Mitch Pileggi
Lawrence Jennings (6 eps)
Leven Rambin
Sloan Riley (5 eps)
Maurice J. Irvin
Nurse Tyler Christian (5 eps)
Michael O'Neill
Gary Clark (4 eps)
Steven W. Bailey
Joe (3 eps)
Jeff Perry
Thatcher Grey (2 eps)
James DuMont
Sheldon Morris (2 eps)
Phil Abrams
Dr. Nelson (2 eps)
Ray Ford
Paramedic Ray (2 eps)
Shannon Lucio
Amanda (2 eps)
Zack Shada
Andy Michaelson (2 eps)
Martha Plimpton
Pam Michaelson (2 eps)
Demi Lovato
Hayley May (1 eps)
Loretta Devine
Adele Webber (1 eps)
Danielle Panabaker
Kelsey Simmons (1 eps)
Cody Christian
Brad (1 eps)
Alanna Masterson
Hillary Boyd (1 eps)
Nicholas Purcell
Doug (1 eps)
Hector Elizondo
Carlos Torres (1 eps)
Sarah Paulson
Young Ellis Grey (1 eps)
T.J. Lowther
Intern Hank (1 eps)
Pamela Reed
Mrs. Banks (1 eps)
Richard T. Jones
Colonel Dan Mooney (1 eps)
Sara Gilbert
Kim Allen (1 eps)
Derek Cecil
Sean Allen (1 eps)
Lance Barber
Phil (1 eps)
Paul Vogt
Aaron Mafrici (1 eps)
Dan Bucatinsky
Jeffrey (1 eps)
Spencer Garrett
Jim Walker (1 eps)
Chastity Dotson
Leslie Wilson (1 eps)
Cynthia Stevenson
Ruthie Carlin (1 eps)
Sinqua Walls
Tom Kates (1 eps)
Frankie Faison
William Bailey (1 eps)
Bruce French
Father Kevin (1 eps)
Kathleen Wilhoite
Leslie Goldman (1 eps)
Khamani Griffin
Wallace Anderson (1 eps)
Erica Gimpel
Bethany Anderson (1 eps)
Derek Webster
Paul Anderson (1 eps)
Angelo Tiffe
Trey Boyd (1 eps)
Joel Grey
Dr. Singer (1 eps)
Mason Cook
Casey (1 eps)
Nathan West
Mike (1 eps)
Hillary Tuck
Julie Jacobson (1 eps)
Tom Amandes
Tom Waller (1 eps)
Isabella Hofmann
Irene Waller (1 eps)
Alexie Gilmore
Sarah Freemont (1 eps)
Ron Roggé
Fire Captain (1 eps)
Bill Fagerbakke
Roy Mackinaw (1 eps)
Erinn Hayes
Cathy Becker (1 eps)
Sarah Utterback
Olivia Harper (1 eps)
James Frain
Tom Crowley (1 eps)
Adrienne Barbeau
Jodie Crowley (1 eps)
Amy Madigan
Katharine Wyatt (1 eps)
Jim Metzler
Priest (1 eps)
Debra Monk
Louise O'Malley (1 eps)
Amy Farrington
Mary May (1 eps)