Billy West
Fry / Professor Farnsworth / Zoidberg / Zapp Brannigan (voice) (144 eps)
Katey Sagal
Leela (voice) (144 eps)
John DiMaggio
Bender (voice) (144 eps)
Tress MacNeille
Mom (voice) (144 eps)
Maurice LaMarche
Morbo / Kif Kroker (voice) (144 eps)
Lauren Tom
Amy Wong (Voice) (144 eps)
Phil LaMarr
Hermes Conrad (voice) (144 eps)
David Herman
Scruffy (voice) (144 eps)
Frank Welker
Nibbler (voice) (127 eps)
Dawnn Lewis
LaBarbara Conrad (voice) (13 eps)
Tom Kenny
Yancy Fry Jr. (voice) (9 eps)
Dan Castellaneta
Robot Devil (voice) (6 eps)
Phil Hendrie
Free Waterfall Junior (voice) (4 eps)
Leonard Nimoy
Leonard Nimoy's Head (Voice) (4 eps)
George Takei
George Takei's Head (voice) (4 eps)
Kath Soucie
Michelle / Rude Boy / Head Museum Feeder (voice) (4 eps)
Al Gore
Al Gore (voice) (3 eps)
Coolio
Kwanzaabot (voice) (3 eps)
Feodor Chin
Leo Wong (voice) (3 eps)
Walter Koenig
Walter Koenig (voice) (2 eps)
Ron Popeil
Ron Popeil's head (voice) (2 eps)
Claudia Schiffer
Claudia Schiffer's head (voice) (2 eps)
Hank Azaria
Harold Zoid (voice) (2 eps)
Dick Clark
Dick Clark's Head (voice) (2 eps)
Rich Little
Rich Little's Head (voice) (2 eps)
Donovan
Himself (2 eps)
Bob Barker
Bob Barker (voice) (2 eps)
Jan Hooks
Anglelyne (voice) (2 eps)
Bea Arthur
Femputer (voice) (2 eps)
Conan O'Brien
Conan O'Brien (2 eps)
Adam Horovitz
Ad-Rock / MCA (voice) (2 eps)
Nora Dunn
Morgan Proctor (voice) (2 eps)
Suzie Plakson
Amazonian (voice) (2 eps)
John Goodman
Robot Santa Claus (voice) (2 eps)
Sigourney Weaver
Planet Express Ship (voice) (2 eps)
Nancy Cartwright
Bart Simpson Doll (voice) (2 eps)
Parker Posey
Umbriel (2 eps)
Michael Diamond
Mike D's head (voice) (2 eps)
William Shatner
William Shatner (voice) (2 eps)
Jonathan Frakes
Jonathan Frakes (voice) (2 eps)
Nichelle Nichols
Nichelle Nichols' Head (voice) (2 eps)
David X. Cohen
Computer (voice) (2 eps)
Stephen Hawking
Stephen Hawking (voice) (2 eps)
Pamela Anderson
Pamela Anderson's head (voice) (2 eps)
Sarah Silverman
Michelle (voice) (2 eps)
Lucy Liu
Lucy Liu's Head (voice) (2 eps)
Cara Delevingne
Makeup Robot (voice) (2 eps)
Kevin Michael Richardson
Barbados Slim (voice) (2 eps)
Gary Gygax
Gary Gygax (voice) (1 eps)
Todd Susman
Announcer (voice) (1 eps)
Pauly Shore
Pauly Shore (voice) (1 eps)
Bob Uecker
Bob Uecker (voice) (1 eps)
Hank Aaron
Hank Aaron (voice) (1 eps)
Roseanne Barr
Roseanne Barr (voice) (1 eps)
Emilia Clarke
Marianne (voice) (1 eps)
Craig Ferguson
Susan Boil (voice) (1 eps)
Chris Elliott
V-Giny (voice) (1 eps)
Katee Sackhoff
Grrrl (voice) (1 eps)
Matt Groening
Self (voice) (1 eps)
Sergio Aragonés
Sergio Aragonés (voice) (1 eps)
Mark Mothersbaugh
Mark Mothersbaugh (voice) (1 eps)
Patton Oswalt
Unattractive Giant Monster (voice) (1 eps)
Buzz Aldrin
Buzz Aldrin (voice) (1 eps)
Wanda Sykes
Bev (voice) (1 eps)
Jill Talley
Trainer (voice) (1 eps)
Estelle Harris
Velma Farnsworth (voice) (1 eps)
Patrick Stewart
Huntmaster (voice) (1 eps)
Larry Bird
Larry Bird (voice) (1 eps)
Robert Wagner
Robert Wagner's Head (voice) (1 eps)
Adam West
Adam West (voice) (1 eps)
Burt Ward
Burt Ward (voice) (1 eps)
Seth MacFarlane
Seymour (voice) (1 eps)
Tara Strong
Tanya (voice) (1 eps)
Karen Maruyama
Amazonian (voice) (1 eps)
Tony Denman
(voice) (1 eps)
Raye Birk
(voice) (1 eps)
Brad Norman
PC (voice) (1 eps)
Patric M. Verrone
Patric M. Verrone (voice) (1 eps)
Dee Bradley Baker
Rusty the Donkey (voice) (1 eps)
Kyle MacLachlan
Dung Beetle (voice) (1 eps)
Ego Nwodim
Dung Beetle Shaman (voice) (1 eps)
Mark Hamill
Chanukah Zombie (voice) (1 eps)
Bill Nye
Bill Nye the Science Head (voice) (1 eps)
Kathy Griffin
Captain Cranky (voice) (1 eps)
Beck
Beck's head (voice) (1 eps)
Russ Leatherman
Mr. Moviefone (voice) (1 eps)
Bob Odenkirk
Chaz (voice) (1 eps)
Dan Vebber
Norwegian seed guard (voice) (1 eps)