Seth MacFarlane
Peter Griffin / Brian Griffin / Stewie Griffin / Glenn Quagmire / Tom Tucker (voice) (20 eps)
Alex Borstein
Lois Griffin / Tricia Takanawa / Loretta Brown / Barbara Pewterschmidt (voice) (20 eps)
Mila Kunis
Meg Griffin (voice) (20 eps)
Seth Green
Chris Griffin (voice) (20 eps)
Patrick Warburton
Joe Swanson (voice) (20 eps)
Arif Zahir
Cleveland Brown (voice) (20 eps)
Gary Cole
Principal Shepherd (voice) (9 eps)
Jennifer Tilly
Bonnie Swanson (voice) (7 eps)
Kevin Michael Richardson
Arby's Announcer (voice) (7 eps)
Rachael MacFarlane
Meg Griffin (singing voice) (7 eps)
Sanaa Lathan
Donna Tubbs (voice) (6 eps)
Sam Elliott
Wild Wild West (voice) (5 eps)
Ralph Garman
Piece of Pizza / Detective (voice) (5 eps)
Peter Macon
Preston Lloyd (voice) (4 eps)
John Viener
Deliverman (voice) (4 eps)
Jay Pharoah
Timothy Q. Mouse (voice) (3 eps)
Chris Parnell
Doug (voice) (2 eps)
Steve Callaghan
Mr. Andy (voice) (2 eps)
Damien Fahey
Horse (voice) (2 eps)
Josh Robert Thompson
James Taylor (voice) (2 eps)
Fred Tatasciore
Airport Clerk (voice) (2 eps)
Jeff Bergman
Fred Flintstone (voice) (1 eps)
H. Jon Benjamin
Bob Belcher (voice) (1 eps)
Martha MacIsaac
Patty (voice) (1 eps)
Mario López
Mario Lopez (voice) (1 eps)
Artie Johann
Baby on Big Wheel (voice) (1 eps)
Naomi Ekperigin
Therapist (voice) (1 eps)
Travis Bowe
Inspector Daniels (voice) (1 eps)
Toks Olagundoye
Auctioneer (voice) (1 eps)
Emmy Raver-Lampman
Mary Elizabeth Becca Ryan (voice) (1 eps)
Ignacio Serricchio
Adult Fan (voice) (1 eps)
Nicole Sullivan
Amber (voice) (1 eps)
Max Charles
Preschooler (voice) (1 eps)
Charlet Chung
Preschooler / Mother (voice) (1 eps)
Courtenay Taylor
Preschooler / Mother (voice) (1 eps)
Mae Whitman
Meg Ryan (voice) (1 eps)
Gerald McRaney
Old West (voice) (1 eps)
Luke Lowe
T. J. (voice) (1 eps)
Chris Regan
Prowler (voice) (1 eps)
Gilbert Gottfried
Gilbert Gottfried (voice) (1 eps)
Matthew Yang King
Waiter (voice) (1 eps)
Kyle McCarley
Harry Potter (voice) (1 eps)
Martha Plimpton
Stephanie (voice) (1 eps)
Karan Brar
Chase (voice) (1 eps)
Casey Wilson
Dottie (voice) (1 eps)
Richard Kind
Rabbi Goldstein (voice) (1 eps)
Joy Osmanski
Party Guest (voice) (1 eps)